Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway.
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DOI: 10.1016/j.intimp.2020.106681
Abstract: Studying and understanding the mechanism of inflammation in nucleus pulposus is the key to understand and prevent intervertebral disc degeneration. We propose a model of mechanical sensitive ion channel Piezo1 mediated inflammation of nucleus pulposus… read more here.
Keywords: ca2 pathway; nucleus pulposus; piezo1; pulposus cells ... See more keywords