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   Articles with "ca2 release" as a keyword



Alleviation of palmitic acid‐induced endoplasmic reticulum stress by augmenter of liver regeneration through IP3R‐controlled Ca2+ release

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recommendations! Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26463

Abstract: The aberrant release of Ca2+ from the endoplasmic reticulum (ER) contributes to the onset of ER stress, which is closely related to the pathogenesis of non‐alcoholic fatty liver disease. We previously reported that augmenter of… read more here.

Keywords: endoplasmic reticulum; ip3r; ca2 release; stress ... See more keywords

Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells.

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recommendations! Published in 2017 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-3-319-57732-6_18

Abstract: Many cellular functions of the vascular endothelium are regulated by fine-tuned global and local, microdomain-confined changes of cytosolic free Ca2+ ([Ca2+]i). Vasoactive agonist-induced stimulation of vascular endothelial cells (VECs) typically induces Ca2+ release through IP3… read more here.

Keywords: endothelium; vascular endothelial; ca2 release; endothelial cells ... See more keywords
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Probing Ca2+ release mechanisms using sea urchin egg homogenates.

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recommendations! Published in 2019 at "Methods in cell biology"

DOI: 10.1016/bs.mcb.2018.10.007

Abstract: Sea urchin eggs have been extensively used to study Ca2+ release through intracellular Ca2+-permeable channels. Their amenability to homogenization yields a robust, cell-free preparation that was central to establishing the Ca2+ mobilizing actions of cyclic… read more here.

Keywords: egg homogenates; sea urchin; ca2 release; ca2 ... See more keywords

Automatic Detection and Classification of Ca2+ Release Events in Line- and Frame-Scan Images.

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recommendations! Published in 2019 at "Biophysical journal"

DOI: 10.1016/j.bpj.2018.12.013

Abstract: Analysis of Ca2+ signals obtained in various cell types (i.e., cardiomyocytes) is always a tradeoff between acquisition speed and signal/noise ratio of the fluorescence signal. This becomes especially apparent during fast two- or three-dimensional confocal… read more here.

Keywords: line; scan images; ca2 release; ca2 ... See more keywords
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Ca2+ Release via IP3 Receptors Shapes the Cardiac Ca2+ Transient for Hypertrophic Signaling.

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recommendations! Published in 2020 at "Biophysical journal"

DOI: 10.1016/j.bpj.2020.08.001

Abstract: Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ from ryanodine receptors for cellular contraction, whereas signaling downstream of G-protein-coupled… read more here.

Keywords: hypertrophic signaling; ca2 release; cycle; ca2 ... See more keywords

Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons.

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recommendations! Published in 2021 at "Cell calcium"

DOI: 10.1016/j.ceca.2021.102399

Abstract: Neuronal Ca2+ signals are fundamental for synaptic transmission and activity-dependent changes in gene expression. Voltage-gated Ca2+ channels and N-methyl-d-aspartate receptors play major roles in mediating external Ca2+ entry during action potential firing and glutamatergic activity.… read more here.

Keywords: ca2 signals; ca2 release; ip3; ca2 ... See more keywords
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JPT2: The missing link between intracellular Ca2+ release channels and NAADP?

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recommendations! Published in 2021 at "Cell calcium"

DOI: 10.1016/j.ceca.2021.102405

Abstract: NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca2+ from endolysosomes through two-pore channels (TPCs) and from the endoplasmic reticulum (ER) through type 1 ryanodine receptors (RyR1). How NAADP activates these… read more here.

Keywords: link intracellular; link; ca2 release; jpt2 missing ... See more keywords
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Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3

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recommendations! Published in 2021 at "Cell Reports"

DOI: 10.1016/j.celrep.2021.109932

Abstract: Summary Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels that link extracellular stimuli to Ca2+ signals. Ca2+ release from intracellular stores is “quantal”: low IP3 concentrations rapidly release a fraction of the stores. Ca2+ release… read more here.

Keywords: quantal ca2; ca2 release; release mediated; responses ip3 ... See more keywords

A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia.

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recommendations! Published in 2017 at "Heart rhythm"

DOI: 10.1016/j.hrthm.2016.10.015

Abstract: BACKGROUND Ventricular fibrillation may be caused by premature ventricular contractions (PVCs) whose coupling intervals are read more here.

Keywords: torsades pointes; ca2 release; short coupled; ca2 ... See more keywords

TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-48988-6

Abstract: The protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for fork protection involves TRPV2-mediated Ca2+ release from the ER, which is triggered… read more here.

Keywords: replication; trpv2 mediated; release; mediated ca2 ... See more keywords

Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1.

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recommendations! Published in 2024 at "Biochemical Society transactions"

DOI: 10.1042/bst20230815

Abstract: An important calcium (Ca2+) entry pathway into the cell is the Ca2+ release-activated Ca2+ (CRAC) channel, which controls a series of downstream signaling events such as gene transcription, secretion and proliferation. It is composed of… read more here.

Keywords: orai1; ca2; release activated; ca2 release ... See more keywords