Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.11.006
Abstract: Mutations in cardiac troponin T (TnT) associated with hypertrophic cardiomyopathy generally lead to an increase in the Ca2+ sensitivity of contraction and susceptibility to arrhythmias. In contrast, TnT mutations linked to dilated cardiomyopathy decrease the… read more here.
Keywords: het; ca2 sensitivity; myofilament ca2; sensitivity ... See more keywords
The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.161
Abstract: Substitution of Arg for Gly residue in 91th position in β-tropomyosin caused by a point mutation in TPM2 gene is associated with distal arthrogryposis, characterized by a high Ca2+-sensitivity of myofilament and contracture syndrome. To… read more here.
Keywords: high ca2; tropomyosin; ca2 sensitivity; atpase cycle ... See more keywords
Assessment of Ca2+ Sensitivity of SK Channels in Rat Ventricular Cardiomyocytes using Intrinsic CA2+ Cycling Machinery
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.572
Abstract: Small conductance Ca2+ activated K+ (SK) channels are thought to play significant roles in ventricular arrhythmias. It has been hypothesized that increase in Ca2+ sensitivity is the main underlying cause of functional upregulation of SKs… read more here.
Keywords: ca2 sensitivity; assessment ca2; sensitivity; sensitivity channels ... See more keywords
Deoxycholylglycine, a conjugated secondary bile acid, reduces vascular tone by attenuating Ca2+ sensitivity via rho kinase pathway
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.04.012
Abstract: ABSTRACT Patients with cirrhosis have reduced systemic vascular resistance and elevated circulating bile acids (BAs). Previously, we showed that secondary conjugated BAs impair vascular tone by reducing vascular smooth muscle cell (VSMC) Ca2+ influx. In… read more here.
Keywords: ca2 sensitivity; tone; vascular tone; vasoconstriction ... See more keywords
Relationship between uterine smooth muscular CPI-17-signal pathway-mediated Ca2+ sensitivity changes and uterine atony-induced postpartum haemorrhage
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2018.1504206
Abstract: Abstract This study aimed to investigate the changes of protein kinase C (PKC)-potentiated phosphatase inhibitor of 17 ku (CPI-17) expression, PKC activity and Rho kinase activity in the maternal uterine smooth muscle (USM), and their… read more here.
Keywords: ca2 sensitivity; uai pph; cpi; cpi signal ... See more keywords
Stimulating Calcium Handling in hiPSC-Derived Engineered Cardiac Tissues Enhances Force Production
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szab002
Abstract: Abstract Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have profound utility in generating functional human engineered cardiac tissues (ECT) for heart repair. However, the field at large is concerned about the relative immaturity of these hiPSC-CMs… read more here.
Keywords: calcium; hipsc cms; ca2 sensitivity; force ... See more keywords
Effects of mavacamten on Ca2+ sensitivity of contraction as sarcomere length varied in human myocardium
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15271
Abstract: Heart failure can reflect impaired contractile function at the myofilament level. In healthy hearts, myofilaments become more sensitive to Ca2+ as cells are stretched. This represents a fundamental property of the myocardium that contributes to… read more here.
Keywords: ca2 sensitivity; myocardium; effects mavacamten; contraction ... See more keywords
Influence of 4 weeks of downhill running on calcium sensitivity of rat single muscle fibers
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15450
Abstract: Improved Ca2+ sensitivity has been suggested as a mechanism behind enhancements in muscle mechanical function following eccentric training. However, little is known regarding the effects of eccentric training on single muscle fiber Ca2+ sensitivity. Adult… read more here.
Keywords: sensitivity; single muscle; ca2 sensitivity; force ... See more keywords
Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21124421
Abstract: Substitution of Ala for Glu residue in position 173 of γ-tropomyosin (Tpm3.12) is associated with muscle weakness. Here we observe that this mutation increases myofilament Ca2+-sensitivity and inhibits in vitro actin-activated ATPase activity of myosin… read more here.
Keywords: ca2 sensitivity; muscle weakness; myosin heads; ca2 ... See more keywords
MgADP Promotes Myosin Head Movement toward Actin at Low [Ca2+] to Increase Force Production and Ca2+-Sensitivity of Contraction in Permeabilized Porcine Myocardial Strips
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315084
Abstract: Myosin cross-bridges dissociate from actin following Mg2+-adenosine triphosphate (MgATP) binding. Myosin hydrolyses MgATP into inorganic phosphate (Pi) and Mg2+-adenosine diphosphate (ADP), and release of these hydrolysis products drives chemo-mechanical energy transitions within the cross-bridge cycle… read more here.
Keywords: contraction; sensitivity contraction; mgadp; ca2 sensitivity ... See more keywords