The Coupling of Gradient Mechano‐Electrical Microenvironments Promotes Interface Regeneration via Ca2⁺ Signaling Activation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202521662
Abstract: The natural tendon‐bone interface achieves stress dispersion through its gradient arrangement of collagen fibers and mineralization; however, surgical repair often leads to stress concentration and regeneration failure. To address this issue, an implantable, magnetically responsive… read more here.
Keywords: interface regeneration; ca2 signaling; gradient mechano; mechano electrical ... See more keywords
Current and Future Landscape of SERCAs' Functions in Non‐Excitatory Cells and Diseases
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DOI: 10.1002/bies.70029
Abstract: Calcium (Ca2+) signaling as the primary intracellular second messenger orchestrates a myriad of physiological processes. Maintaining Ca2+ homeostasis relies on Ca2+ channels, pumps, exchangers, and buffers. Sarco/endoplasmic reticulum Ca2+‐ATPases (SERCAs or ATP2A) encoded by ATP2A1,… read more here.
Keywords: excitatory cells; non excitatory; ca2 signaling; current future ... See more keywords
Dilation of cortical capillaries is not related to astrocyte calcium signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24119
Abstract: The brain requires an adequate supply of oxygen and nutrients to maintain proper function as neuronal activity varies. This is achieved, in part, through neurovascular coupling mechanisms that mediate local increases in blood flow through… read more here.
Keywords: astrocyte ca2; dilation; ca2 signaling; whisker stimulation ... See more keywords
Piezo1 channel‐mediated Ca2+ signaling inhibits lipopolysaccharide‐induced activation of the NF‐κB inflammatory signaling pathway and generation of TNF‐α and IL‐6 in microglial cells
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24311
Abstract: Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the mechanical properties of CNS microenvironments influence glial cell phenotypes, but the mechanisms… read more here.
Keywords: activation; microglial cells; piezo1 channel; ca2 signaling ... See more keywords
Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres
Sign Up to like & getrecommendations! Published in 2018 at "Science China Life Sciences"
DOI: 10.1007/s11427-018-9315-6
Abstract: The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and… read more here.
Keywords: progenitor cells; ca2 signaling; neurons glia; stem progenitor ... See more keywords
Regulation of cardiac Ca2+ and ion channels by shear mechanotransduction
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-017-0929-7
Abstract: Cardiac contraction is controlled by a Ca2+ signaling sequence that includes L-type Ca2+ current-gated opening of Ca2+ release channels (ryanodine receptors) in the sarcoplasmic reticulum (SR). Local Ca2+ signaling in the atrium differs from that… read more here.
Keywords: shear mechanotransduction; ca2 signaling; ion; ca2 ... See more keywords
The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monster.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.03.006
Abstract: Cancer is a leading cause of death worldwide. All major tumor suppressors and oncogenes are now recognized to have fundamental connections with metabolic pathways. A hallmark feature of cancer cells is a reprogramming of their… read more here.
Keywords: mitochondria ca2; cancer; signaling cancer; ca2 ... See more keywords
Astroglial Ca2+ signaling is generated by the coordination of IP3R and store-operated Ca2+ channels.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.096
Abstract: Astrocytes play key roles in the central nervous system and regulate local blood flow and synaptic transmission via intracellular calcium (Ca2+) signaling. Astrocytic Ca2+ signals are generated by multiple pathways: Ca2+ release from the endoplasmic… read more here.
Keywords: store operated; ca2 signaling; astrocytic ca2; ca2 ... See more keywords
Ca2+ signaling, apoptosis and autophagy in the developing cochlea: Milestones to hearing acquisition.
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.05.006
Abstract: In mammals, the sense of hearing arises through a complex sequence of morphogenetic events that drive the sculpting of the auditory sensory epithelium into its terminally functional three-dimensional shape. While the majority of the underlying… read more here.
Keywords: apoptosis autophagy; hearing acquisition; ca2 signaling; ca2 ... See more keywords
A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca2+ signaling in human cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell Calcium"
DOI: 10.1016/j.ceca.2018.08.002
Abstract: Abstract The Ca2+ mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) regulates intracellular trafficking events, including translocation of certain enveloped viruses through the endolysosomal system. Targeting NAADP-evoked Ca2+ signaling may therefore be an effective… read more here.
Keywords: naadp evoked; system; ca2 signaling; sea urchin ... See more keywords
Mutation in RyR2-FKBP Binding site alters Ca2+ signaling modestly but increases "arrhythmogenesis" in human stem cells derived cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102500
Abstract: AIMS To gain insights into FKBP regulation of cardiac ryanodine receptor (RyR2) and Ca2+ signaling, we introduced the point mutation (N771D-RyR2) corresponding to skeletal muscle mutation (N760D-RyR1) associated with central core disease (CCD) via CRISPR/Cas9… read more here.
Keywords: ryr2 fkbp; ryr2; ca2 signaling; ca2 ... See more keywords