Control of Ca2+ signals by astrocyte nanoscale morphology at tripartite synapses
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24258
Abstract: Much of the Ca2+ activity in astrocytes is spatially restricted to microdomains and occurs in fine processes that form a complex anatomical meshwork, the so-called spongiform domain. A growing body of literature indicates that those… read more here.
Keywords: ca2 signals; morphology; microscopy; activity ... See more keywords
Characterization of Different Localized Ca2+ Signals in Skeletal Muscle Fibers
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2620
Abstract: Discrete localized Ca2+ signals (LCS) occur in many cell types. In skeletal muscle fibers they have been shown e.g. to be elicited as a result of an osmotic shock or mechanical skinning of isolated muscle… read more here.
Keywords: skeletal muscle; ca2 signals; muscle; muscle fibers ... See more keywords
The regulation of autophagy by calcium signals: Do we have a consensus?
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.08.005
Abstract: Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates via vesicular engulfment of cellular materials and culminates in their degradation via lysosomal… read more here.
Keywords: ca2 signals; regulation autophagy; autophagic flux; autophagy ... See more keywords
Ryanodine receptor-mediated Ca2+ release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca2+ signals in primary hippocampal neurons.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102399
Abstract: Neuronal Ca2+ signals are fundamental for synaptic transmission and activity-dependent changes in gene expression. Voltage-gated Ca2+ channels and N-methyl-d-aspartate receptors play major roles in mediating external Ca2+ entry during action potential firing and glutamatergic activity.… read more here.
Keywords: ca2 signals; ca2 release; ip3; ca2 ... See more keywords
Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.02.043
Abstract: Summary Astroglia regulate neurovascular coupling while engaging in signal exchange with neurons. The underlying cellular machinery is thought to rely on astrocytic Ca2+ signals, but what controls their amplitude and waveform is poorly understood. Here,… read more here.
Keywords: astroglial ca2; ca2 signals; ca2 controls; resting ca2 ... See more keywords
Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.03.010
Abstract: The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts… read more here.
Keywords: cell dendrites; ca2 signals; purkinje cell; activity ... See more keywords
Structural basis of astrocytic Ca2+ signals at tripartite synapses
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15648-4
Abstract: Astrocytic Ca2+ signals can be fast and local, supporting the idea that astrocytes have the ability to regulate single synapses. However, the anatomical basis of such specific signaling remains unclear, owing to difficulties in resolving… read more here.
Keywords: tripartite synapses; astrocytic ca2; ca2 signals; structural basis ... See more keywords
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24739-9
Abstract: Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile IP3Rs,… read more here.
Keywords: ca2 signals; krap tethers; ca2 puffs; ca2 ... See more keywords
CaMello-XR enables visualization and optogenetic control of Gq/11 signals and receptor trafficking in GPCR-specific domains
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0292-y
Abstract: The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors (5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular signaling domain. Visualizing traffic-dependent GPCR signals in neurons is difficult, but… read more here.
Keywords: ca2 signals; gpcr; receptor trafficking; localization ... See more keywords
Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2004183117
Abstract: Significance Ca2+ signaling is closely linked to the triggering of plant immune responses. We show that when the bacterial elicitor peptide flg22 is used to trigger immune responses in mutants missing tonoplast Ca2+ pumps, it… read more here.
Keywords: ca2 signals; tonoplast; immune responses; ca2 ... See more keywords
Intravital calcium imaging in myeloid leukocytes identifies calcium frequency spectra as indicators of functional states
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abe6909
Abstract: The assessment of leukocyte activation in vivo is mainly based on surrogate parameters, such as cell shape changes and migration patterns. Consequently, additional parameters are required to dissect the complex spatiotemporal activation of leukocytes during… read more here.
Keywords: ca2 signals; inflammation; frequency; microscopy ... See more keywords