Arrhythmogenic late Ca2+ sparks in failing heart cells and their control by action potential configuration
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918649117
Abstract: Significance Sudden cardiac death in heart failure is a major unsolved clinical problem that is linked to the development of a spontaneous arrhythmia. Early afterdepolarizations (EADs) are an arrhythmogenic mechanism, but the cellular trigger for… read more here.
Keywords: ca2 sparks; heart; ca2; late ca2 ... See more keywords
Compartmentalized β1-Adrenergic Signaling Synchronizes Excitation-contraction Coupling Without Modulating Individual Ca2+ Sparks in Healthy and Hypertrophied Cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular research"
DOI: 10.1093/cvr/cvaa013
Abstract: AIMS β-Adrenergic receptors (βARs) play pivotal roles in regulating cardiac excitation-contraction (E-C) coupling. Global signaling of β1ARs upregulates both the influx of Ca2+ through sarcolemmal L-type Ca2+ channels (LCCs) and the release of Ca2+ from… read more here.
Keywords: ca2 sparks; contraction coupling; excitation; ca2 ... See more keywords
Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes
Sign Up to like & getrecommendations! Published in 2018 at "Royal Society Open Science"
DOI: 10.1098/rsos.171462
Abstract: Ca2+ sparks and Ca2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca2+ release events from the junctional sarcoplasmic reticulum (JSR). Based on the anomalous subdiffusion of Ca2+ in the cytoplasm, a… read more here.
Keywords: ca2 sparks; cardiac myocytes; rogue ryanodine; effects rogue ... See more keywords
Age attenuates the T‐type CaV3.2‐RyR axis in vascular smooth muscle
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DOI: 10.1111/acel.13134
Abstract: Caveolae position CaV3.2 (T‐type Ca2+ channel encoded by the α‐3.2 subunit) sufficiently close to RyR (ryanodine receptors) for extracellular Ca2+ influx to trigger Ca2+ sparks and large‐conductance Ca2+‐activated K+ channel feedback in vascular smooth muscle.… read more here.
Keywords: ca2 sparks; cav3 ryr; cav3; smooth muscle ... See more keywords
The Role of Ca2+ Sparks in Force Frequency Relationships in Guinea Pig Ventricular Myocytes
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111577
Abstract: Calcium sparks are the elementary Ca2+ release events in excitation-contraction coupling that underlie the Ca2+ transient. The frequency-dependent contractile force generated by cardiac myocytes depends upon the characteristics of the Ca2+ transients. A stochastic computational… read more here.
Keywords: ca2 sparks; frequency; force frequency; model ... See more keywords