Ca2+ Release via IP3 Receptors Shapes the Cardiac Ca2+ Transient for Hypertrophic Signaling.
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DOI: 10.1016/j.bpj.2020.08.001
Abstract: Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ from ryanodine receptors for cellular contraction, whereas signaling downstream of G-protein-coupled… read more here.
Keywords: hypertrophic signaling; ca2 release; cycle; ca2 ... See more keywords
The Trend of β3-Adrenergic Receptor in the Development of Septic Myocardial Depression: A Lipopolysaccharide-Induced Rat Septic Shock Model
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DOI: 10.1159/000487126
Abstract: Septic shock with low cardiac output is very common in children. However, the mechanism underlying myocardial depression is unclear. The role of β3-AR in the development of myocardial depression in sepsis is unknown. In the… read more here.
Keywords: depression; septic shock; ca2 transient; development ... See more keywords
The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations
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DOI: 10.7554/elife.36717
Abstract: Conductances of ion channels and transporters controlling cardiac excitation may vary in a population of subjects with different cardiac gene expression patterns. However, the amount of variability and its origin are not quantitatively known. We… read more here.
Keywords: transient feedback; ca2 transient; sensor controlling; ionic conductances ... See more keywords