A study of the mechanisms of excitation–contraction coupling in frog skeletal muscle based on measurements of [Ca2+] transients inside the sarcoplasmic reticulum
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Muscle Research and Cell Motility"
DOI: 10.1007/s10974-018-9497-9
Abstract: Abstract[Ca2+] transients inside the sarcoplasmic reticulum (SR) were recorded in frog skeletal muscle twitch fibers under voltage clamp using the low affinity indicator Mag Fluo 4 (loaded in its AM form) with the purpose of… read more here.
Keywords: ca2 transients; muscle; resting ca2; ca2 ... See more keywords
Electropermeabilization of cells by closely spaced paired nanosecond-range pulses.
Sign Up to like & getrecommendations! Published in 2018 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2018.01.013
Abstract: Decreasing the time gap between two identical electric pulses is expected to render bioeffects similar to those of a single pulse of equivalent total duration. In this study, we show that it is not necessarily… read more here.
Keywords: spaced paired; ca2 transients; electropermeabilization; closely spaced ... See more keywords
Stochastic reaction-diffusion modeling of calcium dynamics in 3D-dendritic spines of Purkinje Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.03.027
Abstract: Calcium (Ca2+) is a second messenger assumed to control changes in synaptic strength in the form of both long-term depression (LTD) and long-term potentiation (LTP) at Purkinje cell dendritic spine synapses via inositol trisphosphate (IP3)… read more here.
Keywords: ca2 transients; purkinje cell; reaction diffusion; ca2 ... See more keywords
Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2016.12.013
Abstract: BACKGROUND Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Calcitriol may also induce rapid responses via plasma membrane-associated VDR, involving… read more here.
Keywords: ca2 transients; type calcium; mouse ventricular; calcitriol ... See more keywords
Detection of genetic cardiac diseases by Ca2+ transient profiles using machine learning methods
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27695-5
Abstract: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have revolutionized cardiovascular research. Abnormalities in Ca2+ transients have been evident in many cardiac disease models. We have shown earlier that, by exploiting computational machine learning methods, normal… read more here.
Keywords: machine; machine learning; ca2 transients; genetic cardiac ... See more keywords
Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba1195
Abstract: Left-right (L-R) asymmetric intraciliary calcium transient at the node is the determinant of L-R axis in mice. Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing… read more here.
Keywords: left right; ca2 transients; mouse embryo; symmetry ... See more keywords
Acellular hemoglobin impairs calcium release and contractility in cardiomyocytes from healthy animals
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733896
Abstract: Hemoglobin (Hb)-based oxygen (O2) carriers (HBOC) have been proposed as an alternative for blood transfusion. Phase III clinical trials of previous HBOC generations presented issues, such as vasoconstriction and myocardial infarction, that were not detected… read more here.
Keywords: cmcs; ca2 transients; physiology; release ... See more keywords
Increased Ca2+ signaling in NRXN1α+/− neurons derived from ASD induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Autism"
DOI: 10.1186/s13229-019-0303-3
Abstract: BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder with a high co-morbidity of epilepsy and associated with hundreds of rare risk factors. NRXN1 deletion is among the commonest rare genetic factors shared by ASD, schizophrenia,… read more here.
Keywords: neurons derived; ca2 transients; increased ca2; derived asd ... See more keywords
Imaging and Analysis of Presynaptic Calcium Influx in Cultured Neurons Using synGCaMP6f
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2019.00012
Abstract: Presynaptic Ca2+ influx through voltage-gated calcium channels (VGCCs) is a key step in synaptic transmission that links action potential (AP)-derived depolarization to vesicle release. However, investigation of presynaptic Ca2+ influx by patch clamp recordings is… read more here.
Keywords: ca2 transients; presynaptic calcium; presynaptic ca2; ca2 ... See more keywords
Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00097
Abstract: γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive. In this study, we characterized the expression and… read more here.
Keywords: evoked single; ca2 transients; transients evoked; myenteric neurons ... See more keywords
Physiological Ca2+ Transients Versus Pathological Steady-State Ca2+ Elevation, Who Flips the ROS Coin in Skeletal Muscle Mitochondria
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.595800
Abstract: Mitochondria are both the primary provider of ATP and the pivotal regulator of cell death, which are essential for physiological muscle activities. Ca2+ plays a multifaceted role in mitochondrial function. During muscle contraction, Ca2+ influx… read more here.
Keywords: state; skeletal muscle; ca2 transients; muscle ... See more keywords