Reciprocal Polarization of the Mitochondrial Ca2+ Uniporter and NA+-CA2+ Exchanger in Cardiac Muscle
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DOI: 10.1016/j.bpj.2016.11.729
Abstract: Control of myocardial energetics by Ca2+ signal propagation to the mitochondrial matrix includes local Ca2+ delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial membrane (IMM) through the Ca2+ uniporter (mtCU). Ca2+… read more here.
Keywords: ca2 exchanger; cardiac muscle; ca2 uniporter; ca2 ... See more keywords
Targeting the mitochondrial Ca2+ uniporter complex in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13946
Abstract: Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of Ca2+ uptake dynamics through the mitochondrial Ca2+ uniporter (MCU) complex. In particular, Ca2+ uptake regulates the… read more here.
Keywords: mitochondrial ca2; mcu complex; ca2 uniporter; ca2 ... See more keywords