Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.08.025
Abstract: The type 2a sarco/endoplasmic reticulum (ER) Ca2+-ATPase (SERCA2a) plays a key role in intracellular Ca2+ regulation in the heart. We have previously shown evidence of stable homodimers of SERCA2a in heterologous cells and cardiomyocytes. However,… read more here.
Keywords: dimerization; transport; serca2a; rate ... See more keywords
Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102895
Abstract: Summary The mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane that is involved in various cellular processes. The components of this uniporter, including the pore-forming membrane subunit MCU and the modulatory… read more here.
Keywords: uniporter; uptake regulation; characterization mitochondrial; ca2 uptake ... See more keywords
SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.2
Abstract: Mitochondrial calcium ([Ca2+]m) overload and changes in mitochondrial metabolism are key players in neuronal death. Small conductance calcium-activated potassium (SK) channels provide protection in different paradigms of neuronal cell death. Recently, SK channels were identified… read more here.
Keywords: mitochondrial respiration; death; sk2 channels; ca2 uptake ... See more keywords
Targeting the mitochondrial Ca2+ uniporter complex in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13946
Abstract: Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of Ca2+ uptake dynamics through the mitochondrial Ca2+ uniporter (MCU) complex. In particular, Ca2+ uptake regulates the… read more here.
Keywords: mitochondrial ca2; mcu complex; ca2 uniporter; ca2 ... See more keywords
MLN alters SERCA1a and SERCA2a kinetics but does not alter the apparent coupling ratio
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735123
Abstract: The sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) are responsible for inducing muscle relaxation and are integral to the maintenance of intracellular calcium (Ca2+) homeostasis. As such, their activity is modulated by multiple regulatory proteins. Myoregulin (MLN) is… read more here.
Keywords: presence; mln; physiology; coupling ratio ... See more keywords
A Quantitative Assay for Ca2+ Uptake through Normal and Pathological Hemichannels
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137337
Abstract: Connexin (Cx) hemichannels (HCs) are large pore hexameric structures that allow the exchange of ions, metabolites and a variety of other molecules between the cell cytoplasm and extracellular milieu. HC inhibitors are attracting growing interest… read more here.
Keywords: normal pathological; quantitative assay; uptake normal; pathological hemichannels ... See more keywords