Randomized multicenter phase II trial of prophylactic irradiation of para‐aortic lymph nodes in advanced cervical cancer according to tumor hypoxia: Korean Radiation Oncology Group (KROG 07‐01) study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34190
Abstract: We conducted a prospective phase II study on whether extended‐field irradiation (EFI) confers survival benefits depending on hypoxic markers in locally advanced uterine cervical cancer (LAUCC). RNA‐seq was performed to identify immune and hypoxic gene… read more here.
Keywords: cervical cancer; oncology; double positive; ca9 ... See more keywords
Exosomes expressing carbonic anhydrase 9 promote angiogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.107
Abstract: Exosomes or microvesicles that are secreted from cells are considered to play important roles in tumor microenvironment. Carbonic anhydrase 9 (CA9), which is induced by hypoxia-inducible factor 1 (HIF1) in response to hypoxia, is overexpressed… read more here.
Keywords: carbonic anhydrase; angiogenesis; ca9 exosomes; exosomes expressing ... See more keywords
Identification of the important role of CA9 in immune infiltration and prognosis in cervical cancer
Sign Up to like & getrecommendations! Published in 2025 at "Future Science OA"
DOI: 10.1080/20565623.2025.2532314
Abstract: Abstract Aim This study aimed to investigate the association between CA9 expression and the immune infiltration and prognosis of CC. Materials & Methods The GSE9750 dataset in the GEO database, the UALCAN database, and the… read more here.
Keywords: immune infiltration; infiltration prognosis; study; ca9 ... See more keywords
Abstract 4088: A neovasculature-inducible CA9 CAR resistant to FASL and TGFb mediated suppression for the treatment of ccRCC
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4088
Abstract: Clinically effective CAR-T cell therapy for solid tumors, such as clear cell renal cell carcinoma (ccRCC), will require substantial T cell engineering to increase their specificity and potency. We have developed an Integrated Circuit T… read more here.
Keywords: cell; ccrcc; ca9; ca9 car ... See more keywords
Abstract 5111: Targeting the dysadherin/CA9 axis inhibits colorectal cancer adaptation and growth within the acidic tumor microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5111
Abstract: The tumor microenvironment (TME) has a significant impact on colorectal cancer (CRC) progression by promoting tumor survival and aggressive behavior. A key player in this process is the tumor-associated glycoprotein dysadherin, which is highly expressed… read more here.
Keywords: cancer; crc; tumor; ca9 ... See more keywords
Abstract B49: Development and characterization of a novel CA9 targeting dual-antibody T-cell engager for renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-b49
Abstract: The survival benefit of checkpoint immunotherapies is currently limited, with de novo and acquired resistance to therapy occurring in over 75% of patients. A major mechanism of resistance accounting for these poor responses is a… read more here.
Keywords: ca9; immunology; dual antibody; cell ... See more keywords
Abstract B037: AB-2100, a PSMA-inducible CA9-specific CAR T cell product intended for the treatment of ccRCC provides long-term tumor responses in preclinical mouse model
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Immunology Research"
DOI: 10.1158/2326-6074.tumimm24-b037
Abstract: Common challenges of CAR-T cell therapies in solid tumors, such as clear cell renal cell carcinoma (ccRCC), include insufficient therapeutic potency and tumor specificity. AB-2100 is an autologous integrated circuit T cell product generated via… read more here.
Keywords: ccrcc; car; tumor; cell ... See more keywords
Development of AB-2100, an autologous integrated circuit T (ICT) cell therapy targeting CA9 intended for the treatment of ccRCC.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.4_suppl.472
Abstract: 472 Background: Relapsed/refractory clear cell renal cell carcinoma (ccRCC) progressing after treatment with CPI and VEGF inhibitor remains an area of unmet need. We have developed AB-2100, an autologous, integrated circuit T (ICT) cell engineered… read more here.
Keywords: ccrcc; treatment; logic; cell ... See more keywords
Impact of CA9 expression in the diagnosis of lymph-node metastases in non-small cell lung cancer based on [18F]FDG PET/CT
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DOI: 10.1371/journal.pone.0312846
Abstract: Background Lung cancer is the leading cause of the global cancer incidence and mortality. It is important to obtain an accurate diagnosis of lymph-node metastasis before surgery to select the therapeutic strategy for non-small cell… read more here.
Keywords: 18f fdg; fdg pet; lymph node; ca9 ... See more keywords
Gene expression of carbonic anhydrase 9 (CA9) in de novo acute leukemia as a predictive marker for prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicine and Life"
DOI: 10.25122/jml-2021-0212
Abstract: Carbonic anhydrase 9 (CA9) is a marker for decreased O2 concentration and acidosis, associated with poor prognosis in cancerous patients. The current study suggested that the changes in CA9 gene expression level might be used… read more here.
Keywords: prognosis; marker; ca9; expression ... See more keywords
Impact of Neoadjuvant Bevacizumab on Neuroradiographic Response and Histological Findings Related to Tumor Stemness and the Hypoxic Tumor Microenvironment in Glioblastoma: Paired Comparison Between Newly Diagnosed and Recurrent Glioblastomas
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.898614
Abstract: Background Previously, we reported that bevacizumab (Bev) produces histological and neuroradiographic alterations including changes in tumor oxygenation, induction of an immunosupportive tumor microenvironment, and inhibition of stemness. To confirm how those effects vary during Bev… read more here.
Keywords: ca9; newly diagnosed; stemness; bev ... See more keywords