Treatment of refractory germ-cell tumours with single-agent cabazitaxel: a German Testicular Cancer Study Group case series
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-03071-2
Abstract: Purpose Outcomes of multiply relapsed, refractory germ-cell tumour (GCT) patients remain poor with an overall survival (OS) of a few months only. Thus, new therapeutic advances are urgently needed. Cabazitaxel has shown preclinical activity in… read more here.
Keywords: gct; refractory germ; case series; cabazitaxel ... See more keywords
Prognostic significance of third-line treatment for patients with metastatic castration-resistant prostate cancer: comparative assessments between cabazitaxel and other agents
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-021-01956-2
Abstract: Cabazitaxel has played an important role in the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC); however, several types of sequential therapy against mCRPC have been performed in routine clinical practice. The objective of… read more here.
Keywords: third line; cabazitaxel; line; treatment patients ... See more keywords
Activity of cabazitaxel in patients with metastatic castration-resistant prostate cancer after treatment with single or dual regimens of novel androgen receptor-targeting agents
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-017-1024-0
Abstract: The purpose of this study was to evaluate the efficacy of cabazitaxel for patients with metastatic castration-resistant prostate cancer (mCRPC) after sequential therapy with docetaxel (DTX) and single or dual regimens of novel androgen receptor-axis-targeted… read more here.
Keywords: cabazitaxel; treatment; group; regimens novel ... See more keywords
An analysis of health-related quality of life in the phase III PROSELICA and FIRSTANA studies assessing cabazitaxel in patients with metastatic castration-resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "ESMO Open"
DOI: 10.1016/j.esmoop.2021.100089
Abstract: Background Men with metastatic castration-resistant prostate cancer (mCRPC) are living longer, therefore optimizing health-related quality of life (HRQL), as well as survival outcomes, is important for optimal patient care. The aim of this study was… read more here.
Keywords: prostate; cabazitaxel; hrql; metastatic castration ... See more keywords
Results of a phase II randomized controlled clinical trial comparing efficacy of Cabazitaxel versus Docetaxel as second line or above therapy in recurrent head and neck cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.10.018
Abstract: BACKGROUND Cabazitaxel has shown activity in squamous cancer cell lines and in taxane resistant cell lines. Hence we planned a phase 2 study to evaluate the efficacy of cabazitaxel against Docetaxel in recurrent head and… read more here.
Keywords: neck cancer; cabazitaxel; line; versus ... See more keywords
Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c01205
Abstract: Intravenously administered chemotherapeutic cabazitaxel is used for palliative treatment of prostate cancer. An oral formulation would be more patient-friendly and reduce the need for hospitalization. We therefore study determinants of the oral pharmacokinetics of cabazitaxel… read more here.
Keywords: mice; ritonavir boosted; anion transporting; organic anion ... See more keywords
Supramolecular Amphiphilic Polymer-Based Micelles with Seven-Armed Polyoxazoline Coating for Drug Delivery.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.6b14464
Abstract: Supramolecular polymer micelles composed of seven-armed poly(2-methy-2-oxazoline) as the coating and linear poly(dl-lactide) as the core were prepared through synthesizing β-cyclodextrin-terminated poly(2-methy-2-oxazoline) and adamantine-terminated linear poly(dl-lactide), followed by host-guest interaction between β-cyclodextrin and adamantine groups… read more here.
Keywords: cabazitaxel; seven armed; amphiphilic polymer; drug ... See more keywords
Development of a Plasmonic Sensor for a Chemotherapeutic Agent Cabazitaxel
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05327
Abstract: Drug dosage is a crucial subject in both human and animal treatment. Administering less drug dosage may prevent treatment or make it less effective, and high drug dosage may cause a heightened risk of adverse… read more here.
Keywords: cabazitaxel; drug dosage; chemotherapeutic agent; agent cabazitaxel ... See more keywords
Prostate cancer: Enzalutamide–cabazitaxel interactions
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.212
Abstract: A substantial reduction in cabazitaxel exposure occurs when this drug is given in combination with enzalutamide for metastatic castration-resistant prostate cancer (mCRPC), according to the authors of a new study. “Preclinical data suggest enhanced efficacy… read more here.
Keywords: drug; cancer enzalutamide; prostate cancer; cabazitaxel ... See more keywords
Microfluidic self-assembly of high cabazitaxel loading albumin nanoparticles.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr10941b
Abstract: Cabazitaxel (CTX) is a promising anticancer drug. In this study, CTX-loaded human serum albumin (HSA) nanoparticles (MF-NPs-CTX) were prepared by a microfluidic (MF) method and were evaluated for tumor inhibition in PC-3 and HeLa cells… read more here.
Keywords: self assembly; assembly high; cabazitaxel; nps ctx ... See more keywords
Use of nanoemulsion for co-delivery of silibinin and cabazitaxel for prostate cancer treatment
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2025.2552392
Abstract: Abstract Objective This study introduces a novel nanoemulsion (NE) system co-loaded with silibinin (SIL) and cabazitaxel (CBX) to address limitations, such as poor solubility, low bioavailability, and systemic toxicities of these agents. Significance SIL/CBX-loaded NE… read more here.
Keywords: cbx; prostate cancer; nanoemulsion; sil cbx ... See more keywords