Miniature mass spectrometer–based point-of-care assay for cabotegravir and rilpivirine in whole blood
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DOI: 10.1007/s00216-022-03954-3
Abstract: HIV prevention and treatment with injectable cabotegravir and/or rilpivirine administered once every 4 to 8 weeks is an attractive alternative to daily therapy. Prescribed dosage and drug concentrations in plasma are based on patient data… read more here.
Keywords: miniature; cabotegravir rilpivirine; mass; cabotegravir ... See more keywords
An evaluation of long-acting cabotegravir + rilpivirine for the treatment of virologically suppressed adults living with HIV
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2126310
Abstract: ABSTRACT Introduction HIV is a global disease that has seen significant improvements in care over the past decades. Despite improvements, treatments for maintaining suppression are complex for patients and include two to three oral medications.… read more here.
Keywords: living hiv; treatment; cabotegravir rilpivirine; hiv ... See more keywords
Acute Hepatitis B Infection After a Switch to Long-Acting Cabotegravir and Rilpivirine
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DOI: 10.1093/ofid/ofaa367
Abstract: Abstract Maintenance antiretroviral therapy with combination of two injectable long-acting drugs, cabotegravir and rilpivirine, is a new strategy addressing the challenges of daily adherence to oral pills that has shown non-inferior efficacy to standard of… read more here.
Keywords: long acting; hepatitis infection; acute hepatitis; infection switch ... See more keywords
Long-Term Efficacy, Safety, and Durability of Cabotegravir and Rilpivirine as 2-Drug Oral Maintenance Therapy After 6 Years of Study
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DOI: 10.1093/ofid/ofac067
Abstract: Abstract Background In the LATTE study, daily oral cabotegravir + rilpivirine demonstrated higher rates of efficacy than efavirenz + 2 nucleoside reverse-transcriptase inhibitors (NRTIs) through Week 96 in antiretroviral therapy (ART)-naive adults with human immunodeficiency… read more here.
Keywords: maintenance; therapy; cabotegravir rilpivirine; phase ... See more keywords
Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine
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DOI: 10.1093/ofid/ofad217
Abstract: Abstract Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in… read more here.
Keywords: long acting; cabotegravir rilpivirine; virological failure; gynoid fat ... See more keywords
Monthly injectable cabotegravir/rilpivirine to manage HIV infection in adults
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Association of Nurse Practitioners"
DOI: 10.1097/jxx.0000000000000729
Abstract: ABSTRACT The FDA recently approved a unique treatment regimen for management of HIV-1 infection in adults. A one-time per month injection of cabotegravir/rilpivirine can replace a current, stable antiretroviral regimen in those with virologic suppression,… read more here.
Keywords: infection adults; cabotegravir rilpivirine; hiv infection; cabotegravir ... See more keywords
Safety and efficacy of long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection: a systematic review and meta-analysis protocol
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DOI: 10.1136/bmjopen-2022-063089
Abstract: Background Current antiretroviral regimens have, for the most part, achieved optimal antiretroviral efficacy and tolerability, transforming HIV infection from a deadly disease into a manageable chronic condition. However, adherence to daily oral drug intake remains… read more here.
Keywords: systematic review; efficacy; analysis; cabotegravir rilpivirine ... See more keywords
Real-Life Therapeutic Concentration Monitoring of Long-Acting Cabotegravir and Rilpivirine: Preliminary Results of an Ongoing Prospective Observational Study in Switzerland
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DOI: 10.3390/pharmaceutics14081588
Abstract: SHCS#879 is an ongoing Switzerland-wide multicenter observational study conducted within the Swiss HIV Cohort Study (SHCS) for the prospective follow-up of people living with HIV (PLWH) receiving long-acting injectable cabotegravir-rilpivirine (LAI-CAB/RPV). All adults under LAI-CAB/RPV… read more here.
Keywords: concentration; observational study; cabotegravir rilpivirine; monitoring ... See more keywords