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   Articles with "cacna1c" as a keyword



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SA28 ASSOCIATIONS IN THE UK BIOBANK COHORT BETWEEN GENETIC RISK SCORE FOR CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA 1C (CACNA1C) POLYMORPHISMS AND BOTH MOOD DISORDER PHENOTYPES AND CHRONOTYPE PREFERENCE

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recommendations! Published in 2019 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2017.08.100

Abstract: Background Variants of the Calcium Voltage-Gated Channel Subunit Alpha 1 C (CACNA1C) gene have been associated with several neuropsychiatric disorders, most notably Bipolar Disorder (BD) (Cross Disorder Group of PGC., 2013). Previous studies of the function… read more here.

Keywords: chronotype preference; cacna1c; disorder phenotypes; mood disorder ... See more keywords
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A dual-virus strategy for the deletion of cacan1c within the prelimbic to nucleus accumbens core projection

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recommendations! Published in 2020 at "Molecular Psychiatry"

DOI: 10.1038/s41380-020-00886-1

Abstract: Fig. 1 This image illustrates the knockdown of cacna1c within the prelimbic (PrL) cortex to nucleus accumbens core (NAcC) projection in mice. a In cacna1c-floxed mice, an adeno associated virus (AAV) expressing flp-dependent cre recombinase… read more here.

Keywords: strategy; gfp; cacna1c; projection ... See more keywords
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Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased anxiety

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2108768119

Abstract: Significance The gene CACNA1C encodes for a calcium channel that has been linked to various psychiatric conditions, including schizophrenia and bipolar disorder, through hitherto unknown cellular mechanisms. Here, we report that deletion of Cacna1c in… read more here.

Keywords: gene; brain development; cacna1c; activity ... See more keywords
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Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species

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recommendations! Published in 2018 at "Schizophrenia Bulletin"

DOI: 10.1093/schbul/sby146

Abstract: Abstract Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Cav1.2 L-type voltage-gated calcium channels (VGCCs), has been strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. How genetic variation in… read more here.

Keywords: risk; variation cacna1c; cacna1c; reversal learning ... See more keywords
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A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder

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recommendations! Published in 2022 at "Pediatric neurology"

DOI: 10.1101/2022.06.22.22276784

Abstract: CACNA1C encodes the voltage gated L-type calcium channel CaV1.2. A specific gain of function pathogenic variant in CACNA1C causes Timothy syndrome type 1 (TS1) with cardiac long QT syndrome, syndactyly, and neuropsychiatric symptoms. Recent case… read more here.

Keywords: phenotype; cacna1c related; related disorder; neuropsychiatric symptoms ... See more keywords

CACNA1C Gene rs11832738 Polymorphism Influences Depression Severity by Modulating Spontaneous Activity in the Right Middle Frontal Gyrus in Patients With Major Depressive Disorder

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recommendations! Published in 2020 at "Frontiers in Psychiatry"

DOI: 10.3389/fpsyt.2020.00073

Abstract: Objectives This study aimed to examine whether the CACNA1C gene rs11832738 polymorphism and major depressive disorder (MDD) have an interactive effect on the untreated regional amplitude of low-frequency fluctuation (ALFF) and to determine whether regional… read more here.

Keywords: rs11832738 polymorphism; cacna1c; alff; depression severity ... See more keywords
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Analysis of CACNA1C and KCNH2 Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes13112132

Abstract: Background: Cardiac autonomic dysfunction (CADF) is a major contributor to increased cardiac mortality in schizophrenia patients. The aberrant function of voltage-gated ion channels, which are widely distributed in the brain and heart, may link schizophrenia… read more here.

Keywords: cardiac autonomic; cacna1c kcnh2; risk; cacna1c ... See more keywords