Quantification of egg ovalbumin hydrolysate-derived anti-hypertensive peptides in an in vitro model combining luminal digestion with intestinal Caco-2 cell transport.
Sign Up to like & getrecommendations! Published in 2017 at "Food research international"
DOI: 10.1016/j.foodres.2017.06.002
Abstract: Food-derived peptides can impact blood pressure through several mechanisms. However, their fate in the gastro-intestinal tract and bioavailability are difficult to assess because of their fast degradation and challenging analysis in physiologically relevant matrices. The… read more here.
Keywords: egg ovalbumin; digestion; cell transport; luminal digestion ... See more keywords
Biopharmaceutics classification evaluation for paris saponin VII.
Sign Up to like & getrecommendations! Published in 2020 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(20)60010-3
Abstract: To study the biopharmaceutics characteristics of paris saponin VII (PSVII). The solubility of PSVII was evaluated by measurement of the equilibrium solubility in different solvents and media. The permeability of PSVII was evaluated by measuring… read more here.
Keywords: mono layer; layer caco; cell model; psvii ... See more keywords
Bioavailability of Peptides Derived from the In Vitro Digestion of Human Milk Assessed by Caco-2 Cell Monolayers.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01246
Abstract: Human milk-protein-derived peptides exhibit an array of bioactivities. Certain bioactivities cannot be exerted unless the peptides are absorbed across the gastrointestinal lumen into the bloodstream. The purpose of study was to determine which peptides derived… read more here.
Keywords: caco cell; human milk; milk; peptides derived ... See more keywords
Absorption rates and mechanism of avenanthramides in Caco-2 cell model and their antioxidant activity during absorption.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06576
Abstract: Avenanthramides (AVNs) were a unique kind of polyphenols which were only detected in the oats and have been demonstrated to exhibit strong antioxidant activities but low bioavailability. The purpose of the present research was to… read more here.
Keywords: absorption; avn avn; cell model; rates mechanism ... See more keywords
Natural Fe isotope fractionation in an intestinal Caco-2 cell line model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Analytical Atomic Spectrometry"
DOI: 10.1039/c7ja00090a
Abstract: In this work, Fe isotopic analysis of samples obtained from an in vitro intestinal model was performed via multi-collector ICP-mass spectrometry (MC-ICP-MS) to evaluate the isotope fractionation accompanying Fe uptake and transport mechanisms at a… read more here.
Keywords: caco cell; model; cell; isotope fractionation ... See more keywords
The effect of lycopene on cytochrome P450 isoenzymes and P-glycoprotein by using human liver microsomes and Caco-2 cell monolayer model
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Food Sciences and Nutrition"
DOI: 10.1080/09637486.2017.1420756
Abstract: Abstract Lycopene is widely used as a dietary supplement. However, the effects of lycopene on cytochrome P450 (CYP) enzymes or P-glycoprotein (P-gp) are not comprehensive. The present study was performed to investigate the effects of… read more here.
Keywords: cell monolayer; lycopene cytochrome; effect; cytochrome p450 ... See more keywords
Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based in vitro monolayer model by activating MAPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab125
Abstract: The widespread use of chlorothalonil (CTL) has caused environmental residues and food contamination. Although the intestinal epithelial barrier (IEB) is directly involved in the metabolism and transportation of various exogenous compounds, there are few studies… read more here.
Keywords: intestinal epithelial; barrier; dysfunction; cell ... See more keywords
Effects of hydrophobicity and molecular weight on the transport permeability of oligopeptides across Caco-2 cell monolayers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13188
Abstract: The objective of this paper was to investigate the effects of hydrophobicity and molecular weight (MW) on the transepithelial transport permeability of oligopeptides across Caco-2 cell monolayers. Results showed that oligopeptides with different N-terminal amino… read more here.
Keywords: cell monolayers; transport; across caco; permeability ... See more keywords
Assessment of the DPP-IV inhibitory activity of a novel octapeptide derived from rapeseed using Caco-2 cell monolayers and molecular docking analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13406
Abstract: The Octapeptide ELHQEEPL, which was identified from the rapeseed protein napin showed prominent Dipeptidyl peptidase-IV (DPP-IV) inhibitory activity. The objective of this study was to investigate the DPP-IV inhibitory activity and transepithelial transport of ELHQEEPL… read more here.
Keywords: cell monolayers; caco cell; activity; dpp inhibitory ... See more keywords
Drug-transporter mediated interactions between anthelminthic and antiretroviral drugs across the Caco-2 cell monolayers
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-017-0129-6
Abstract: BackgroundDrug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a transwell. The impact of anthelminthics on the transport… read more here.
Keywords: cell monolayers; sqv; transport; drug ... See more keywords
Extracellular Signals of a Human Epithelial Colorectal Adenocarcinoma (Caco-2) Cell Line Facilitate the Penetration of Pseudomonas aeruginosa PAO1 Strain through the Mucin Layer
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00415
Abstract: Pseudomonas aeruginosa can penetrate the layer of mucus formed by host intestinal epithelial cells, often resulting in sepsis in immunocompromised patients. We have previously demonstrated that P. aeruginosa can penetrate the mucin layer by flagellar… read more here.
Keywords: mucin layer; layer; caco cell;