Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity.
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DOI: 10.1021/acs.jnatprod.8b00641
Abstract: Four new compounds (2-5) structurally related to the microtubule-stabilizing agent (-)-zampanolide (1) have been isolated from the Tongan marine sponge Cacospongia mycofijiensis. Three of these new structures, zampanolides B-D (2-4), exhibit nanomolar cytotoxicity toward the… read more here.
Keywords: microtubule stabilizing; sponge; sponge cacospongia; marine sponge ... See more keywords