SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.161
Abstract: Aberrant activation of Wnt signaling plays a pivotal role in the development of human cancers including colon cancer. Small compounds that regulate Wnt signaling are attractive candidate for the colon cancer therapy. Here, we showed… read more here.
Keywords: cadherin catenin; growth; colon cancer; colon ... See more keywords
Prevention of epithelial to mesenchymal transition in colorectal carcinoma by regulation of the E-cadherin-β-catenin-vinculin axis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.03.008
Abstract: Epithelial to mesenchymal transition (EMT) is compulsory for metastatic dissemination and is stimulated by TGF-β. Although targeting EMT has significant therapeutic potential, very few pharmacological agents have been shown to exert anti-metastatic effects. BI-69A11, a… read more here.
Keywords: mesenchymal transition; carcinoma; catenin; cadherin catenin ... See more keywords
The cadherin-catenin complex is necessary for cell adhesion and embryogenesis in Nematostella vectensis.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2019.01.007
Abstract: The cadherin-catenin complex is a conserved, calcium-dependent cell-cell adhesion module that is necessary for normal development and the maintenance of tissue integrity in bilaterian animals. Despite longstanding evidence of a deep ancestry of calcium-dependent cell… read more here.
Keywords: catenin; cell adhesion; cadherin catenin; catenin complex ... See more keywords
Variants in members of the cadherin–catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-017-0010-5
Abstract: Blepharocheilodontic syndrome (BCDS) consists of lagophthalmia, ectropion of the lower eyelids, distichiasis, euryblepharon, cleft lip/palate and dental anomalies and has autosomal dominant inheritance with variable expression. We identified heterozygous variants in two genes of the… read more here.
Keywords: cdh1; blepharocheilodontic syndrome; ctnnd1; catenin ... See more keywords
VE‐cadherin N‐glycosylation modified by N‐acetylglucosaminyltransferase V regulates VE‐cadherin–β‐catenin interaction and monocyte adhesion
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Physiology"
DOI: 10.1113/ep089617
Abstract: What is the central question of this study? Inflammation‐induced monocyte adhesion is the initiator of most vascular diseases. The underlying mechanisms that mediate monocyte adhesion remain to be clarified fully. What is the main finding… read more here.
Keywords: glycosylation; adhesion; monocyte adhesion; cadherin catenin ... See more keywords
Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00002
Abstract: Activity of heparanase, responsible for cleavage of heparan sulfate (HS), is strongly implicated in tumor metastasis. This is due primarily to remodeling of the extracellular matrix (ECM) that becomes more prone to invasion by metastatic… read more here.
Keywords: cell cell; heparanase; cell; cadherin catenin ... See more keywords
Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/β-Catenin Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.841918
Abstract: Colorectal cancer (CRC) is a common clinical malignant tumor and closely related to intestinal microbiome disorders. Especially, Fusobacterium nucleatum (F. nucleatum) is one of the most prevalent pathogens in CRC. However, its change in CRC… read more here.
Keywords: ipm711 ipm712; nucleatum; colorectal cancer; fusobacterium nucleatum ... See more keywords
Bacteroides fragilis Toxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 by the E-Cadherin/β-Catenin/NF-κB Dependent Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040827
Abstract: Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote colitis associated cancer in humans. ETBF secretes the metalloprotease, B. fragilis toxin (BFT), which can induce ectodomain cleavage of E-cadherin and… read more here.
Keywords: bft; catenin; secretion; cadherin catenin ... See more keywords