Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage
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DOI: 10.1515/biol-2021-0081
Abstract: Abstract The present research was designed to examine the effects of disintegrin metalloproteinases 10 (ADAM10) on the doxorubicin (DOX)-induced dilated cardiomyopathy (DCM) and the mechanisms involved, with a focus on ADAM10-dependent cleavage of N-cadherin. The… read more here.
Keywords: adam10; cleavage; cardiac remodeling; cadherin cleavage ... See more keywords
The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.940449
Abstract: Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition… read more here.
Keywords: ubc9 sumo; neck cancer; cleavage; head neck ... See more keywords
Inhibition of Vascular Endothelial Cadherin Cleavage Prevents Elastic Fiber Alterations and Atherosclerosis Induced by Intermittent Hypoxia in the Mouse Aorta
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DOI: 10.3390/ijms23137012
Abstract: Intermittent hypoxia (IH), the major feature of obstructive sleep apnea syndrome (OSAS), induces atherosclerosis and elastic fiber alterations. VE-cadherin cleavage is increased in OSAS patients and in an IH-cellular model. It is mediated by HIF-1… read more here.
Keywords: fiber; intermittent hypoxia; elastic fiber; fiber alterations ... See more keywords