Abstract B04: Synthetic lethal targeting of E-cadherin-deficient cancers
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DOI: 10.1158/1557-3265.pmccavuln16-b04
Abstract: Germline mutation of the E-cadherin gene (CDH1) genetically defines the inherited cancer syndrome hereditary diffuse gastric cancer (HDGC). HDGC is characterized by highly penetrant diffuse gastric cancer (DGC) and an elevated rate of lobular breast… read more here.
Keywords: cancer; cell; cadherin deficient; synthetic lethal ... See more keywords
Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells
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DOI: 10.3390/cancers11091359
Abstract: The CDH1 gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric cancer and inactivating germline CDH1 mutations are responsible for hereditary diffuse gastric cancer syndrome (HDGC). Using… read more here.
Keywords: cadherin deficient; akt inhibitors; gastric cancer; target synthetic ... See more keywords
E-Cadherin-Deficient Cells Are Sensitive to the Multikinase Inhibitor Dasatinib
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DOI: 10.3390/cancers14071609
Abstract: Simple Summary Inactivating mutations in the CDH1 gene, encoding the cell adhesion protein E-cadherin, cause hereditary diffuse gastric cancer syndrome (HDGC), as well as being a hallmark of sporadic diffuse gastric cancers and lobular breast… read more here.
Keywords: dasatinib; cadherin; cadherin deficient; deficient cells ... See more keywords