Pancreatic CAF-derived Autotaxin (ATX) drives autocrine CTGF expression to modulate pro-tumorigenic signaling
Sign Up to like & getrecommendations! Published in 2024 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-23-0522
Abstract: Autotaxin (ATX), encoded by ENPP2, is a clinical target in pancreatic ductal adenocarcinoma (PDAC). ATX catalyzes the production of lysophosphatidic acid (LPA), an important regulator within the tumor microenvironment (TME), yet the pro-tumorigenic action of… read more here.
Keywords: pro tumorigenic; caf derived; atx; lpa ... See more keywords
Role of Cancer Associated Fibroblast (CAF) derived miRNAs on head and neck malignancies microenvironment: a systematic review
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-13965-9
Abstract: MicroRNAs (miRNAs) play a key role in regulating gene expression within the tumor microenvironment, influencing cancer progression and therapy response. Cancer-associated fibroblasts (CAFs) contribute to tumor development by secreting exosomal miRNAs that promote proliferation, invasion,… read more here.
Keywords: cancer; derived mirnas; caf derived; head neck ... See more keywords