Analyzing the role of cancer-associated fibroblast activation on macrophage polarization.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13454
Abstract: Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model of murine mammary gland tumors, Snai1… read more here.
Keywords: cafs; polarization; cancer associated; tumor ... See more keywords
Self-Oxygenated Hydrogel Enhances Immune Cell Response and Infiltration Via Triggering Dual DNA Damage to Activate cGAS-STING and Inhibiting CAFs.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202403428
Abstract: Immune checkpoint inhibitors (ICIs) offer promise in breaking through the treatment and survival dilemma of triple-negative breast cancer (TNBC), yet only immunomodulatory subtype and ≈5% TNBC patients respond as monotherapy due to lack of effector… read more here.
Keywords: cafs; immune cell; dna; cgas sting ... See more keywords
Microcystic pattern and shadowing are independent predictors of ovarian borderline tumors and cystadenofibromas in ultrasound
Sign Up to like & getrecommendations! Published in 2020 at "European Radiology"
DOI: 10.1007/s00330-020-07113-z
Abstract: Objectives To determine the sonographic characteristics of borderline tumors (BoTs) and cystadenofibromas (CAFs). Methods Preoperative sonograms from consecutive patients who had at least one primary epithelial tumor in the adnexa were retrospectively collected. All tumors… read more here.
Keywords: borderline tumors; shadowing independent; microcystic pattern; tumors cystadenofibromas ... See more keywords
Oxidized ATM protein kinase is a new signal transduction player that regulates glycolysis in CAFs as well as tumor growth and metastasis
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.02.058
Abstract: It has become clear that cancer associated fibroblasts (CAFs), the mRNA/protein levels with pathway fluxes and phenotypes, are not almost abundant stromal cells in the tumor microenvironment, through the secretion of cytokines and other growth… read more here.
Keywords: glycolysis; cafs; glycolysis cafs; protein kinase ... See more keywords
Cancer-associated fibroblast regulate proliferation and migration of prostate cancer cells through TGF-β signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116791
Abstract: AIMS Prostate cancer (PCa) incidence rates are rising in China currently. Cancer-associated fibroblasts (CAFs), as a major component of tumor microenvironment, are crucial for tumor progression. This study was aimed to explore the promotion effect… read more here.
Keywords: cancer; cafs; proliferation migration; prostate cancer ... See more keywords
Clinical significance of PD-L1-positive cancer-associated fibroblasts in pN0M0 non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.09.013
Abstract: OBJECTIVES Cancer-associated fibroblasts (CAFs) are a dominant cell type in tumor stroma and support the generation of pro-tumorigenic microenvironment. CAFs have frequent opportunities to interact with immune cells infiltrating the tumor stroma, but the process… read more here.
Keywords: cafs; lung cancer; cancer; expression cafs ... See more keywords
Dual role of twist1 in cancer‐associated fibroblasts and tumor cells promoted epithelial‐mesenchymal transition of esophageal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2019.01.002
Abstract: ABSTRACT Cancer‐associated fibroblasts (CAFs) play critical roles in tumor progression. However, the role and mechanism underlying CAFs in esophageal cancer (EC) remain unclear. In this study, primary CAFs and normal esophageal fibroblasts (NOFs) were isolated… read more here.
Keywords: cafs; twist1; associated fibroblasts; role ... See more keywords
Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Cancer"
DOI: 10.1038/s41416-023-02565-8
Abstract: Pancreatic neuroendocrine tumors (PNETs) with low microvessel density and fibrosis often exhibit clinical aggressiveness. Given the contribution of cancer-associated fibroblasts (CAFs) to the hypovascular fibrotic stroma in pancreatic ductal adenocarcinoma, investigating whether CAFs play a… read more here.
Keywords: cancer; pnet; metastasis; cafs ... See more keywords
Thy-1+ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06922-5
Abstract: Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been fully elucidated. Because Thy-1… read more here.
Keywords: cafs; associated fibroblasts; lung cancer; cancer ... See more keywords
Functional prediction of long non-coding RNAs in ovarian cancer-associated fibroblasts indicate a potential role in metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10869-y
Abstract: Cancer-associated fibroblasts (CAFs) contribute to the poor prognosis of ovarian cancer. Unlike in tumour cells, DNA mutations are rare in CAFs, raising the likelihood of other mechanisms that regulate gene expression such as long non-coding… read more here.
Keywords: cafs; associated fibroblasts; metastasis; ovarian cancer ... See more keywords
Brcal Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF)
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32370-w
Abstract: It is known that Cancer Associated Fibroblast (CAFs) from the primary tumor site can accompany cancer cells to a secondary site during the process of metastasis. We hypothesize that these CAFs could be transformed to… read more here.
Keywords: cafs; associated fibroblasts; metastasis; cancer cells ... See more keywords