Investigation on the role of gene hp0788 in Helicobacter pylori in infecting gastric epithelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.103739
Abstract: Helicobacter pylori infection can cause a wide range of digestive diseases. Gene hp0788 encodes an outer membrane protein HofF, which can reduce the bacterial adherence to the GES-1 cells and affect pathogenesis of H. pylori. In… read more here.
Keywords: gene hp0788; caga; 0788 mutant; gene ... See more keywords
Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35937-9
Abstract: Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. A cross-sectional study was… read more here.
Keywords: caga; haemoglobin levels; antibody; sero ... See more keywords
Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47240-2
Abstract: Infection with CagA+ Helicobacter pylori strains is linked to an increased risk for gastric diseases, including gastric cancer. Recent evidence indicates that dynamic expansion and contraction of cagA copy number may serve as a novel… read more here.
Keywords: cagpai type; caga; multi caga; type ... See more keywords
Gastric cancer in Latin America
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2019.1577483
Abstract: Dear Sir, The paper by Ruiz-Garcia et al. on the high incidence of gastric cancer in Latin America is an important one [1]. They hypothesize that regional variation in incidence might arise from differences in… read more here.
Keywords: caga; gastric cancer; latin america; cancer latin ... See more keywords
vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000660
Abstract: Purpose. Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele‐dependent. The aims of this work… read more here.
Keywords: chronic gastritis; caga baba2; vaca s1m1; caga ... See more keywords
Helicobacter pylori-induced DNA double-strand break in the development of gastric cancer.
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DOI: 10.1111/cas.15357
Abstract: Infection with cagA-positive Helicobacter pylori strains plays an etiological role in the development of gastric cancer. The CagA protein is injected into gastric epithelial cells through a bacterial Type IV secretion system. Inside the host… read more here.
Keywords: cancer; pylori; development gastric; helicobacter pylori ... See more keywords
Dynamic Expansion and Contraction of cagA Copy Number in Helicobacter pylori Impact Development of Gastric Disease
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DOI: 10.1128/mbio.01779-16
Abstract: ABSTRACT Infection with Helicobacter pylori is a major risk factor for development of gastric disease, including gastric cancer. Patients infected with H. pylori strains that express CagA are at even greater risk of gastric carcinoma.… read more here.
Keywords: caga copy; gastric disease; caga; disease ... See more keywords
Association between serum vitamin D levels and Helicobacter pylori cytotoxic-associated gene A seropositivity: a cross-sectional study in US adults from NHANES III
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-058164
Abstract: Objective To assess the association of serum vitamin D (VD) levels and Helicobacter pylori (H. pylori) cytotoxic-associated gene A (CagA) seropositivity, and further explore potential effect modifiers in this association. Design Cross-sectional study. Setting Data… read more here.
Keywords: seropositivity; serum; nhanes iii; caga ... See more keywords
Increased H. pylori stool shedding and EPIYA-D cagA alleles are associated with gastric cancer in an East Asian hospital
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DOI: 10.1371/journal.pone.0202925
Abstract: Background Helicobacter pylori infection increases risk for gastric cancer. Geographic variation in gastric cancer risk has been attributed to variation in carriage and type of the H. pylori oncogene cagA. Colonization density may also influence… read more here.
Keywords: caga; gastric cancer; pylori load; cancer ... See more keywords
Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells
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DOI: 10.18632/oncotarget.23050
Abstract: Infection with cagA-positive Helicobacter pylori is associated with a higher risk of gastric cancer. The cagA gene product, CagA, is translocated into gastric epithelial cells and perturbs host cellular biological functions. Etoposide, a topoisomerase II… read more here.
Keywords: apoptosis; gastric cancer; caga; etoposide induced ... See more keywords
A review of signal pathway induced by virulent protein CagA of Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1062803
Abstract: Gastric cancer (GC), a common and high-mortality disease, still occupies an important position in current cancer research, and Helicobacter pylori (H. pylori) infection as its important risk factor has been a hot and challenging research… read more here.
Keywords: protein caga; signaling pathway; caga; helicobacter pylori ... See more keywords