Investigation on the role of gene hp0788 in Helicobacter pylori in infecting gastric epithelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.103739
Abstract: Helicobacter pylori infection can cause a wide range of digestive diseases. Gene hp0788 encodes an outer membrane protein HofF, which can reduce the bacterial adherence to the GES-1 cells and affect pathogenesis of H. pylori. In… read more here.
Keywords: gene hp0788; caga; 0788 mutant; gene ... See more keywords
Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35937-9
Abstract: Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. A cross-sectional study was… read more here.
Keywords: caga; haemoglobin levels; antibody; sero ... See more keywords
Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47240-2
Abstract: Infection with CagA+ Helicobacter pylori strains is linked to an increased risk for gastric diseases, including gastric cancer. Recent evidence indicates that dynamic expansion and contraction of cagA copy number may serve as a novel… read more here.
Keywords: cagpai type; caga; multi caga; type ... See more keywords
CaGA nanozymes with multienzyme activity realize multifunctional repair of acute wounds by alleviating oxidative stress and inhibiting cell apoptosis.
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials science"
DOI: 10.1039/d4bm01155d
Abstract: Acute wounds result from damage to the skin barrier, exposing underlying tissues and increasing susceptibility to bacterial and other pathogen infections. Improper wound care increases the risk of exposure and infection, often leading to chronic… read more here.
Keywords: acute wounds; caga; cell; caga nanozymes ... See more keywords
Gastric cancer in Latin America
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2019.1577483
Abstract: Dear Sir, The paper by Ruiz-Garcia et al. on the high incidence of gastric cancer in Latin America is an important one [1]. They hypothesize that regional variation in incidence might arise from differences in… read more here.
Keywords: caga; gastric cancer; latin america; cancer latin ... See more keywords
AUF1-mediated inhibition of autophagic lysosomal degradation contributes to CagA stability and Helicobacter pylori-induced inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Gut Microbes"
DOI: 10.1080/19490976.2024.2382766
Abstract: ABSTRACT CagA, a virulence factor of Helicobacter pylori (H. pylori), is known to drive inflammation in gastric epithelial cells and is typically degraded through autophagy. However, the molecular mechanism by which CagA evades autophagy-mediated degradation… read more here.
Keywords: degradation; caga; pylori; inflammation ... See more keywords
Déjà vu all over again (Yogi Berra)
Sign Up to like & getrecommendations! Published in 2024 at "BioScience"
DOI: 10.1093/biosci/biae128
Abstract: A quick examination of the history of scientific discovery related to microbial pathogenesis confirms that scientists follow a predictable pattern of investigation. Typically, key virulence factors are identified and vaccines or therapies are designed to… read more here.
Keywords: caga; gene; gastroduodenal disease; virulence factors ... See more keywords
vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000660
Abstract: Purpose. Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele‐dependent. The aims of this work… read more here.
Keywords: chronic gastritis; caga baba2; vaca s1m1; caga ... See more keywords
Helicobacter pylori-induced DNA double-strand break in the development of gastric cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15357
Abstract: Infection with cagA-positive Helicobacter pylori strains plays an etiological role in the development of gastric cancer. The CagA protein is injected into gastric epithelial cells through a bacterial Type IV secretion system. Inside the host… read more here.
Keywords: cancer; pylori; development gastric; helicobacter pylori ... See more keywords
Dynamic Expansion and Contraction of cagA Copy Number in Helicobacter pylori Impact Development of Gastric Disease
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DOI: 10.1128/mbio.01779-16
Abstract: ABSTRACT Infection with Helicobacter pylori is a major risk factor for development of gastric disease, including gastric cancer. Patients infected with H. pylori strains that express CagA are at even greater risk of gastric carcinoma.… read more here.
Keywords: caga copy; gastric disease; caga; disease ... See more keywords
Association between serum vitamin D levels and Helicobacter pylori cytotoxic-associated gene A seropositivity: a cross-sectional study in US adults from NHANES III
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-058164
Abstract: Objective To assess the association of serum vitamin D (VD) levels and Helicobacter pylori (H. pylori) cytotoxic-associated gene A (CagA) seropositivity, and further explore potential effect modifiers in this association. Design Cross-sectional study. Setting Data… read more here.
Keywords: seropositivity; serum; nhanes iii; caga ... See more keywords