Elucidation of the working principle of a gene-directed caged HDAC inhibitor with cell-type selectivity.
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DOI: 10.1039/d2cc03552a
Abstract: Histone deacetylases (HDACs) play crucial roles in the epigenetic regulation of gene expression. Here, we report CM-Bhc-SAHA, a novel caged HDAC inhibitor, genetically targeting cells of interest. Mammalian cells expressing porcine liver esterase led to… read more here.
Keywords: gene; hdac inhibitor; caged hdac; elucidation working ... See more keywords