A point mutation in human coilin prevents Cajal body formation.
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DOI: 10.1242/jcs.259587
Abstract: Coilin is a conserved protein essential for integrity of nuclear membrane-less inclusions called Cajal bodies. Here, we report an amino-acid substitution (p.K496E) found in a widely-used human EGFP-coilin construct that has a dominant negative effect… read more here.
Keywords: cajal body; body formation; human coilin; cajal bodies ... See more keywords