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   Articles with "calcific aortic" as a keyword



Crosstalk between myofibroblasts and macrophages: A regulative factor of valvular fibrosis in calcific aortic valve disease

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11980

Abstract: Inflammation and fibrosis are highly correlated with the progression of calcific aortic valve disease (CAVD). As one of the differentiated forms of valvular interstitial cells, myofibroblasts play a critical role in CAVD's development as do… read more here.

Keywords: aortic valve; myofibroblasts macrophages; valve disease; crosstalk myofibroblasts ... See more keywords

Jatrorrhizine Alleviates Calcific Aortic Valve Disease via Interfering With Glycolysis Targeting ALDOA K42 Lactylation

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.8504

Abstract: Calcific aortic valve disease (CAVD) is a common cardiovascular disorder. It is characterized by the thickening, fibrosis, and mineralization of aortic valve leaflets. These pathological changes can progress to heart failure if not managed effectively.… read more here.

Keywords: jat; valve; lactylation; aortic valve ... See more keywords
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A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.

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recommendations! Published in 2022 at "Cell reports"

DOI: 10.1016/j.celrep.2022.110685

Abstract: Cellular heterogeneity of aortic valves complicates the mechanistic evaluation of the calcification processes in calcific aortic valve disease (CAVD), and animal disease models are lacking. In this study, we identify a disease-driver population (DDP) within… read more here.

Keywords: calcific aortic; profiling; cell; disease ... See more keywords

Exploring potential genes and pathways related to calcific aortic valve disease.

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recommendations! Published in 2021 at "Gene"

DOI: 10.1016/j.gene.2021.145987

Abstract: Calcific aortic valve disease (CAVD) is currently the most prevalent valvular disease. However, the pathological mechanism of CAVD has not yet been fully elucidated, and no drugs can delay or halt the progression of CAVD.… read more here.

Keywords: aortic valve; disease; calcific aortic; valve disease ... See more keywords
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Soluble FMS-Like Tyrosine Kinase-1 Is a Circulating Biomarker Associated With Calcific Aortic Stenosis.

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recommendations! Published in 2019 at "Journal of the American College of Cardiology"

DOI: 10.1016/j.jacc.2019.01.020

Abstract: Calcific aortic stenosis (CAS) is the end manifestation of calcific aortic valve disease (CAVD). There are no medical therapies to reverse or slow the progression of CAVD [(1)][1]. Circulating biomarkers may provide insights into CAVD… read more here.

Keywords: like tyrosine; aortic stenosis; soluble fms; calcific aortic ... See more keywords

Oral Anticoagulation Therapy and Progression of Calcific Aortic Valve Stenosis.

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recommendations! Published in 2019 at "Journal of the American College of Cardiology"

DOI: 10.1016/j.jacc.2019.01.043

Abstract: Calcific aortic valve stenosis (AS) is the most prevalent valvular heart disease in high-income countries [(1)][1], and currently there is no pharmacotherapy known to prevent its progression. Oral anticoagulants are the benchmark for preventing thromboembolic… read more here.

Keywords: progression; valve stenosis; aortic valve; calcific aortic ... See more keywords
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PREDICTORS OF CALCIFIC AORTIC VALVE STENOSIS PROGRESSION AS MEASURED BY CHANGE IN PEAK VELOCITY: A META-ANALYSIS AND META-REGRESSION

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recommendations! Published in 2020 at "Journal of the American College of Cardiology"

DOI: 10.1016/s0735-1097(20)32799-6

Abstract: Identifying patients at risk of progression of Calcific Aortic Valve Stenosis (pCAVS) is important for optimal timing of diagnosis and treatment. Systematic review was conducted in accordance with the PRISMA guidelines. Search was preformed using… read more here.

Keywords: valve stenosis; aortic valve; meta; calcific aortic ... See more keywords

Multiomics identification of ALDH9A1 as a crucial immunoregulatory molecule involved in calcific aortic valve disease

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-75115-8

Abstract: Mitochondrial dysfunction and immune cell infiltration play crucial yet incompletely understood roles in the pathogenesis of calcific aortic valve disease (CAVD). This study aimed to identify immune-related mitochondrial genes critical to the pathological process of… read more here.

Keywords: mitochondrial genes; valve disease; aortic valve; calcific aortic ... See more keywords
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Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favoring cell death and the severity of disease.

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recommendations! Published in 2021 at "Cardiovascular research"

DOI: 10.1093/cvr/cvab267

Abstract: AIMS In the last 15 years, some observations tried to shed light on the dysregulation of the cellular self-digestion process in calcific aortic valve stenosis (CAVS), but the results obtained remain still controversial. This work is… read more here.

Keywords: valve stenosis; aortic valve; disease; calcific aortic ... See more keywords

Human antigen R regulates autophagic flux by stabilizing autophagy-associated mRNA in calcific aortic valve disease.

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recommendations! Published in 2023 at "Cardiovascular research"

DOI: 10.1093/cvr/cvad077

Abstract: AIMS The incidence of calcific aortic valve disease (CAVD) has risen over the last decade and is expected to continue rising; however, pharmacological approaches have proven ineffective. In this study, we evaluated the role and… read more here.

Keywords: hur; aortic valve; human antigen; valve disease ... See more keywords

Pro-inflammatory monocytes in patients with calcific aortic valve disease

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recommendations! Published in 2025 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvaf148

Abstract: There is a pressing need to elucidate the pathophysiology of calcific aortic valve disease (CAVD), because its prevalence and associated health burden is increasing and there is no pharmacological treatment option. Its risk factors and… read more here.

Keywords: calcific aortic; pro inflammatory; valve disease; aortic valve ... See more keywords