Crosstalk between myofibroblasts and macrophages: A regulative factor of valvular fibrosis in calcific aortic valve disease
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11980
Abstract: Inflammation and fibrosis are highly correlated with the progression of calcific aortic valve disease (CAVD). As one of the differentiated forms of valvular interstitial cells, myofibroblasts play a critical role in CAVD's development as do… read more here.
Keywords: aortic valve; myofibroblasts macrophages; valve disease; crosstalk myofibroblasts ... See more keywords
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110685
Abstract: Cellular heterogeneity of aortic valves complicates the mechanistic evaluation of the calcification processes in calcific aortic valve disease (CAVD), and animal disease models are lacking. In this study, we identify a disease-driver population (DDP) within… read more here.
Keywords: calcific aortic; profiling; cell; disease ... See more keywords
Exploring potential genes and pathways related to calcific aortic valve disease.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145987
Abstract: Calcific aortic valve disease (CAVD) is currently the most prevalent valvular disease. However, the pathological mechanism of CAVD has not yet been fully elucidated, and no drugs can delay or halt the progression of CAVD.… read more here.
Keywords: aortic valve; disease; calcific aortic; valve disease ... See more keywords
Soluble FMS-Like Tyrosine Kinase-1 Is a Circulating Biomarker Associated With Calcific Aortic Stenosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.01.020
Abstract: Calcific aortic stenosis (CAS) is the end manifestation of calcific aortic valve disease (CAVD). There are no medical therapies to reverse or slow the progression of CAVD [(1)][1]. Circulating biomarkers may provide insights into CAVD… read more here.
Keywords: like tyrosine; aortic stenosis; soluble fms; calcific aortic ... See more keywords
Oral Anticoagulation Therapy and Progression of Calcific Aortic Valve Stenosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.01.043
Abstract: Calcific aortic valve stenosis (AS) is the most prevalent valvular heart disease in high-income countries [(1)][1], and currently there is no pharmacotherapy known to prevent its progression. Oral anticoagulants are the benchmark for preventing thromboembolic… read more here.
Keywords: progression; valve stenosis; aortic valve; calcific aortic ... See more keywords
PREDICTORS OF CALCIFIC AORTIC VALVE STENOSIS PROGRESSION AS MEASURED BY CHANGE IN PEAK VELOCITY: A META-ANALYSIS AND META-REGRESSION
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)32799-6
Abstract: Identifying patients at risk of progression of Calcific Aortic Valve Stenosis (pCAVS) is important for optimal timing of diagnosis and treatment. Systematic review was conducted in accordance with the PRISMA guidelines. Search was preformed using… read more here.
Keywords: valve stenosis; aortic valve; meta; calcific aortic ... See more keywords
Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favoring cell death and the severity of disease.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab267
Abstract: AIMS In the last 15 years, some observations tried to shed light on the dysregulation of the cellular self-digestion process in calcific aortic valve stenosis (CAVS), but the results obtained remain still controversial. This work is… read more here.
Keywords: valve stenosis; aortic valve; disease; calcific aortic ... See more keywords
Human antigen R regulates autophagic flux by stabilizing autophagy-associated mRNA in calcific aortic valve disease.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad077
Abstract: AIMS The incidence of calcific aortic valve disease (CAVD) has risen over the last decade and is expected to continue rising; however, pharmacological approaches have proven ineffective. In this study, we evaluated the role and… read more here.
Keywords: hur; aortic valve; human antigen; valve disease ... See more keywords
Rare case of severe non-calcific aortic stenosis in an achondroplastic dwarf: surgical consideration
Sign Up to like & getrecommendations! Published in 2021 at "Interactive Cardiovascular and Thoracic Surgery"
DOI: 10.1093/icvts/ivab335
Abstract: Abstract A 41-year-old patient with achondroplasia who had undergone surgery for congenital aortic stenosis >20 years ago presented with dyspnoea due to severe aortic stenosis. Computed tomography confirmed a small (16-mm) aortic annulus, thickened aortic valve… read more here.
Keywords: aortic root; stenosis; rare case; aortic stenosis ... See more keywords
MicroRNA Expression Signature in Human Calcific Aortic Valve Disease
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/4820275
Abstract: Altered microRNA (miRNA, miR) expression has been related to many disease processes; however, the miRNA expression signature in calcific aortic valve disease (CAVD) is unclear. In this study, microarrays were used to determine the miRNA… read more here.
Keywords: expression signature; disease; expression; calcific aortic ... See more keywords
Upregulation of miR-664a-3p Ameliorates Calcific Aortic Valve Disease by Inhibiting the BMP2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/2074356
Abstract: The development of calcific aortic valve disease (CAVD) is a complex process of ectopic calcification involving various factors that lead to aortic valve stenosis, hemodynamic changes, and, in severe cases, even sudden death. Currently, aortic… read more here.
Keywords: aortic valve; bmp2; mir 664a; disease ... See more keywords