Altering of host larval (Spodoptera exigua) calcineurin activity in response to ascovirus infection.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5615
Abstract: BACKGROUND Calcineurin is involved in numerous of cellular processes and Ca2+-dependent signal transduction pathways. With thousands of host larval (Spodoptera exigua) transcripts are downregulated after the infection of Heliothis virescens ascovirus 3h (HvAV-3h) in our… read more here.
Keywords: secan suba; infection; calcineurin activity; calcineurin ... See more keywords
The Use of Cre/loxP Inducible Mouse Models to Dissect the Specific Roles of Calcineurin Signaling in Myeloid Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9030-6_14
Abstract: The calcineurin/nuclear factor of activated T-cell (NFAT) signaling pathway is important for the development and function of different leukocyte subsets. Calcineurin is activated through increased intracellular levels of calcium that is triggered by cell receptors.… read more here.
Keywords: mouse models; inducible mouse; loxp inducible; calcineurin ... See more keywords
Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti rats
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05751-1
Abstract: Rationale Calcineurin is a protein regulating cytokine expression in T lymphocytes and calcineurin inhibitors such as cyclosporine A (CsA) are widely used for immunosuppressive therapy. It also plays a functional role in distinct neuronal processes… read more here.
Keywords: calcineurin; dark agouti; sensorimotor gating; treatment ... See more keywords
Inhibition of Noncanonical Ca2+ Oscillation/Calcineurin/GSK-3β Pathway Contributes to Anti-Inflammatory Effect of Sigma-1 Receptor Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03439-2
Abstract: Further understanding the mechanism for microglia activation is necessary for developing novel anti-inflammatory strategies. Our previous study found that the activation of sigma-1 receptor can effectively inhibit the neuroinflammation, independent of the canonical mechanisms, such… read more here.
Keywords: anti inflammatory; calcineurin; activation; sigma receptor ... See more keywords
Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.186
Abstract: Studies in yeasts have implicated the importance of Kin1 protein kinase, a member of the eukaryotic PAR1/MARK/MELK family, in polarized growth, cell division and septation through coordinated activity with the phosphatase, calcineurin. Kin1 is also… read more here.
Keywords: aspergillus fumigatus; calcineurin; septum; septation ... See more keywords
The Competition between Electrostatic-Steering and Conformational Dynamics in the Diffusion-Limited Association of Calcineurin and Calmodulin
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.312
Abstract: Calcineurin (CaN) is a serine/threonine phosphatase that regulates a variety of physiological and pathophysiological processes in most mammalian tissue. In its inactive state, the CaN catalytic domain is inhibited by the auto-inhibitory domain (AID); the… read more here.
Keywords: cam; calcineurin; limited association; association ... See more keywords
Dimethyl fumarate exerts neuroprotection by modulating calcineurin/NFAT1 and NFκB dependent BACE1 activity in Aβ1-42 treated neuroblastoma SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.08.024
Abstract: Ample studies signify a key part of calcineurin, a Ca2+/calmodulin-sensitive phosphatase in Alzheimer's disease beginning and/or clinical progression and alteration of calcineurin has been confirmed in the Alzheimer's disease brain, impacting tau proteins and amyloid… read more here.
Keywords: calcineurin; alzheimer disease; treated neuroblastoma; activity ... See more keywords
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102480
Abstract: Calcineurin (CaN), acting downstream of intracellular calcium signals, orchestrates cellular remodeling in many cellular types. In astrocytes, major homeostatic players in the central nervous system (CNS), CaN is involved in neuroinflammation and gliosis, while its… read more here.
Keywords: calcineurin; alzheimer disease; deletion; signature ... See more keywords
Regulation of dual leucine zipper kinase activity through its interaction with calcineurin.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109953
Abstract: Hyperglycemia enhancing the intracellular levels of reactive oxygen species (ROS) contributes to dysfunction and progressive loss of beta cells and thereby to diabetes mellitus. The oxidation sensitive calcium/calmodulin dependent phosphatase calcineurin promotes pancreatic beta cell… read more here.
Keywords: dlk; calcineurin; kinase; dual leucine ... See more keywords
Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.016
Abstract: Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and pathological angiogenesis… read more here.
Keywords: endothelial calcineurin; calcineurin signaling; outgrowth; calcineurin ... See more keywords
Identification of calcineurin as a predictor of oocyte quality and fertilization competence based on microarray data
Sign Up to like & getrecommendations! Published in 2021 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2021.107561
Abstract: OBJECTIVE The aim of our study was to detect a biomarker for selection of competent oocytes with acceptable fertilization potential. Calcium ion fluctuation play the most critical role of modulating intercellular signaling pathways in oocyte… read more here.
Keywords: identification calcineurin; fertilization; calcineurin predictor; calcineurin ... See more keywords