Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures.
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DOI: 10.1016/j.ceca.2021.102480
Abstract: Calcineurin (CaN), acting downstream of intracellular calcium signals, orchestrates cellular remodeling in many cellular types. In astrocytes, major homeostatic players in the central nervous system (CNS), CaN is involved in neuroinflammation and gliosis, while its… read more here.
Keywords: calcineurin; alzheimer disease; deletion; signature ... See more keywords