Are Adverse Events Induced by the Acute Administration of Calcineurin Inhibitor Cyclosporine A Behaviorally Conditioned in Healthy Male Volunteers?
Sign Up to like & getrecommendations! Published in 2018 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.09.008
Abstract: PURPOSE The learned immunosuppressive placebo response has been demonstrated in experimental animals, healthy humans, and patients, and is suggested as a therapy for improving immunopharmacologic treatment. It remains unclear, however, whether potential adverse events induced… read more here.
Keywords: healthy male; events induced; behaviorally conditioned; calcineurin inhibitor ... See more keywords
Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2016.11.007
Abstract: BACKGROUND Calcineurin-inhibitor-induced pain syndrome (CIPS) was used as a reference in the literature as reflex sympathetic dystrophy syndrome related to calcineurin inhibitors. Much of the literature describes CIPS that occurred after kidney and bone marrow… read more here.
Keywords: kidney transplantation; calcineurin inhibitor; transplantation; mmf ... See more keywords
Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis
Sign Up to like & getrecommendations! Published in 2017 at "Bone Marrow Transplantation"
DOI: 10.1038/bmt.2016.241
Abstract: Recombinant human soluble thrombomodulin (rTM) counteracted capillary leakage and alleviated edema in individuals with sinusoidal obstruction syndrome and engraftment syndrome after hematopoietic stem cell transplantation. We previously showed that rTM increased levels of antiapoptotic protein… read more here.
Keywords: src cadherin; cadherin; vascular permeability; calcineurin inhibitor ... See more keywords
Role of low‐dose calcineurin inhibitor regimens in pediatric kidney transplantation
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16159
Abstract: Despite the clinical advancements made in pediatric kidney transplantation, long-term outcomes remain sub-optimal. According to recent data from the North American Pediatric Renal Trial and Collaborative Studies (NAPRTCS), pediatric allograft function and survival continue to… read more here.
Keywords: pediatric kidney; transplantation; kidney transplantation; calcineurin inhibitor ... See more keywords
Delayed calcineurin inhibitor introduction and renal outcomes in liver transplant recipients receiving basiliximab induction
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Transplantation"
DOI: 10.1111/ctr.13415
Abstract: To investigate the impact of delayed calcineurin inhibitor (CNI) initiation in liver transplant recipients (LTR) with peri‐operative renal insufficiency receiving basiliximab induction, we compared renal outcomes of LTR stratified by the degree of achieved post‐operative… read more here.
Keywords: basiliximab induction; calcineurin inhibitor; liver transplant; delayed calcineurin ... See more keywords
Voclosporin: A Novel Calcineurin Inhibitor for the Treatment of Lupus Nephritis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Pharmacotherapy"
DOI: 10.1177/10600280221075331
Abstract: Objective: To describe the safety, efficacy, and potential role in therapy of voclosporin, an oral calcineurin inhibitor approved by the Food and Drug Administration (FDA) in January 2021 as an adjunct treatment for lupus nephritis.… read more here.
Keywords: lupus nephritis; calcineurin inhibitor; nephritis; voclosporin ... See more keywords
Calcineurin-inhibitor free immunosuppression after lung transplantation – a single center case-control study in 51 patients converted to Mechanistic Target of Rapamycin (mTOR) inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0284653
Abstract: Background Data on calcineurin-inhibitor (CNI) free immunosuppression after lung transplantation (LTx) are limited. Aim of this study was to investigate CNI-free immunosuppression using mechanistic target of rapamycin (mTOR) inhibitors. Methods This retrospective analysis was performed… read more here.
Keywords: calcineurin inhibitor; mtor inhibitors; cni free; free immunosuppression ... See more keywords
Everolimus with Reduced Calcineurin Inhibitor Exposure in Renal Transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018010009
Abstract: Background Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the efficacy and safety outcomes of this treatment after kidney transplant require confirmation.Methods In a multicenter noninferiority trial, we randomized 2037 de novo kidney transplant recipients… read more here.
Keywords: everolimus; calcineurin inhibitor; exposure; everolimus reduced ... See more keywords
A phase II/III randomized, multicenter trial of prednisone/sirolimus versus prednisone/ sirolimus/calcineurin inhibitor for the treatment of chronic graft-versus-host disease: BMT CTN 0801
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2018.195123
Abstract: Initial therapy of chronic graft-versus-host disease is prednisone ± a calcineurin-inhibitor, but most patients respond inadequately. In a randomized, adaptive, phase II/III, multicenter trial we studied whether prednisone/sirolimus or prednisone/sirolimus/photopheresis was more effective than prednisone/sirolimus/calcineurin-inhibitor… read more here.
Keywords: prednisone sirolimus; prednisone; versus; calcineurin inhibitor ... See more keywords
Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095110
Abstract: Increasing extracellular osmolarity 100 mOsm/kg above plasma level to the physiological levels for cartilage induces chondrogenic marker expression and the differentiation of chondroprogenitor cells. The calcineurin inhibitor FK506 has been reported to modulate the hypertrophic… read more here.
Keywords: cell; inhibitor fk506; calcineurin inhibitor; osmolarity ... See more keywords