Cost analysis on the use of rituximab and calcineurin inhibitors in children and adolescents with steroid-dependent nephrotic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Nephrology"
DOI: 10.1007/s00467-017-3789-y
Abstract: BackgroundRituximab (RTX) is increasingly being used in place of calcineurin inhibitors (CNI) in pediatric patients with steroid-dependent nephrotic syndrome (SDNS). However, despite its favorable safety profile, its unit cost is prohibitive. We therefore compared the… read more here.
Keywords: calcineurin inhibitors; group; dependent nephrotic; steroid dependent ... See more keywords
Calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene mutations: a systematic review
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Nephrology"
DOI: 10.1007/s00467-020-04695-0
Abstract: Calcineurin inhibitor (CNI) use in genetic steroid-resistant nephrotic syndrome (SRNS) is controversial as response rate is reported to be lower than non-genetic disease and no plausible mechanism of action is known. We reviewed PubMed for… read more here.
Keywords: calcineurin inhibitors; response; inhibitors nephrotic; syndrome secondary ... See more keywords
Calcineurin inhibitors versus cyclophosphamide for idiopathic membranous nephropathy: A systematic review and meta-analysis of 21 clinical trials.
Sign Up to like & getrecommendations! Published in 2017 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2016.12.005
Abstract: OBJECTIVE To compare the efficacy and safety of calcineurin inhibitors (CNIs) with cyclophosphamide (CTX) in the treatment of idiopathic membranous nephropathy (IMN). METHODS A literature search was carried out using PubMed, EMBASE, Cochrane Central Register… read more here.
Keywords: calcineurin inhibitors; tac ctx; efficacy safety; ctx ... See more keywords
Topical calcineurin inhibitors for pediatric periorificial dermatitis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2020.01.064
Abstract: BACKGROUND Data regarding the treatment of periorificial dermatitis (POD) with topical calcineurin inhibitors (TCI) in the pediatric population are limited. OBJECTIVE To assess the clinical utility of TCI in pediatric patients with POD. METHODS A… read more here.
Keywords: periorificial dermatitis; topical calcineurin; calcineurin inhibitors; patients treated ... See more keywords
Calcineurin Inhibitors Nephrotoxicity Prevention Strategies With Stress on Belatacept-Based Rescue Immunotherapy: A Review of the Current Evidence.
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DOI: 10.1016/j.transproceed.2021.03.028
Abstract: BACKGROUND A traditional narrative review was performed to evaluate clinical studies that have examined the clinical implications, risk factors, and prevention of calcineurin inhibitors (CNIs) nephrotoxicity with stress on a belatacept-based rescue regimen. METHODS The… read more here.
Keywords: nephrotoxicity; calcineurin inhibitors; belatacept based; based rescue ... See more keywords
Alzheimer's Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach?
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DOI: 10.1021/acschemneuro.8b00213
Abstract: Therapeutics to effectively treat Alzheimer's disease (AD) are lacking. In vitro, animal and human studies have implicated the excessive activation of the protein phosphatase calcineurin (CN) as an early step in the pathogenesis of AD.… read more here.
Keywords: calcineurin inhibitors; disease dendritic; alzheimer disease; dendritic spines ... See more keywords
Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation
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DOI: 10.1038/s41401-018-0070-2
Abstract: Calcineurin inhibitors (CNIs), such as cyclosporine A and tacrolimus, are widely used immunosuppressive agents for the prevention of post-transplantation rejection and have improved 1-year graft survival rates by up to 90%. However, CNIs can induce… read more here.
Keywords: immunosuppressive therapy; calcineurin inhibitors; organ transplantation; transplantation ... See more keywords
Blood, Cellular, and Tissular Calcineurin Inhibitors PharmacokineticâPharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study
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DOI: 10.1097/ftd.0000000000001025
Abstract: Supplemental Digital Content is Available in the Text. Background: After heart transplantation, calcineurin inhibitors (CNI) (cyclosporin A and tacrolimus) are key immunosuppressive drugs to prevent graft rejection. Whole-blood concentration (Cblood)-guided therapeutic drug monitoring (TDM) is… read more here.
Keywords: heart transplant; intracar study; calcineurin inhibitors; cblood ... See more keywords
Posttransplant Calcineurin Inhibitors Levels and Intrapatient Variability Are Not Associated With Long-term Outcomes Following Liver Transplantation
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DOI: 10.1097/tp.0000000000002987
Abstract: Supplemental Digital Content is available in the text. Background. There is an interest in understanding the association between early calcineurin inhibitors exposure post-liver transplantation (LT) and long-term outcomes. We aimed to analyze this association exploring… read more here.
Keywords: calcineurin inhibitors; liver transplantation; long term; term ... See more keywords
Deciphering the mechanism of calcineurin inhibitorâinduced hypertension
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DOI: 10.1111/apha.13976
Abstract: In the current issue of Acta Physiologica, Gao et al. explore the possible role of the inward rectifying potassium channel (Kir) 4.1 in cyclosporin Ainduced hyperkalemic hypertension.1 Calcineurin inhibitors, such as cyclosporin A and tacrolimus,… read more here.
Keywords: potassium; calcineurin; calcineurin inhibitors; activity ... See more keywords
Response Predictors to Calcineurin Inhibitors in Patients with Primary Membranous Nephropathy
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DOI: 10.1159/000488728
Abstract: Background: Currently, there is an urgent need to find ways of identifying primary membranous nephropathy (PMN) patients who are likely to benefit from calcineurin inhibitors (CNI) or who are resistant to them. In this study,… read more here.
Keywords: pmn patients; calcineurin inhibitors; membranous nephropathy; pla2r antibody ... See more keywords