Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.016
Abstract: Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and pathological angiogenesis… read more here.
Keywords: endothelial calcineurin; calcineurin signaling; outgrowth; calcineurin ... See more keywords
Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Immunity"
DOI: 10.1016/j.immuni.2022.03.008
Abstract: Bacterial sensing by intestinal tumor cells contributes to tumor growth through cell-intrinsic activation of the calcineurin-NFAT axis, but the role of this pathway in other intestinal cells remains unclear. Here, we found that myeloid-specific deletion… read more here.
Keywords: tumor; immunity; calcineurin nfat; b7h3 b7h4 ... See more keywords
Arsenic trioxide restrains lung cancer growth and metastasis by blocking the calcineurin-NFAT pathway by upregulating DSCR1.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220629154619
Abstract: BACKGROUND Anti-angiogenesis therapy mostly aimed at targeting vascular endothelial growth factor (VEGF) and its receptors has been widely applied to lung cancer. However, the improvement in the patient overall survival remains dissatisfying. Previously, we demonstrated… read more here.
Keywords: metastasis; lung cancer; growth; dscr1 ... See more keywords