Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.016
Abstract: Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and pathological angiogenesis… read more here.
Keywords: endothelial calcineurin; calcineurin signaling; outgrowth; calcineurin ... See more keywords
Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis
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DOI: 10.1038/mi.2016.52
Abstract: Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin–nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus… read more here.
Keywords: calcineurin signaling; susceptibility; calcineurin; myeloid cells ... See more keywords
Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00221
Abstract: Despite the central role of amyloid β (Aβ) peptide in the etiopathogenesis of Alzheimer’s disease (AD), its physiological function in healthy brain is still debated. It is well established that elevated levels of Aβ induce… read more here.
Keywords: calcineurin signaling; cdk5 calcineurin; alpha7 acetylcholine; physiological concentrations ... See more keywords