Plasma calcitonin gene‐related peptide (CGRP) in migraine and endometriosis during the menstrual cycle
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51360
Abstract: Migraine, endometriosis, and the comorbidity of both are frequent pain disorders of special relevance for women. The neuropeptide calcitonin gene‐related peptide (CGRP) is critically involved in migraine, and circumstantial evidence suggests a role in endometriosis.… read more here.
Keywords: endometriosis; related peptide; gene related; calcitonin gene ... See more keywords
Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related Peptide.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202103005
Abstract: The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited. Here it is shown that electrical… read more here.
Keywords: fracture; electrical stimulation; gene related; fracture healing ... See more keywords
Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25831
Abstract: Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia. read more here.
Keywords: antagonists worsen; related peptide; gene related; calcitonin gene ... See more keywords
Efficacy and safety of calcitonin gene‐related peptide antagonists in migraine treatment: A meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2542
Abstract: We systematically reviewed the efficacy and safety of Calcitonin Gene‐Related Peptide (CGRP) antagonists for migraine treatment. read more here.
Keywords: calcitonin gene; safety calcitonin; related peptide; antagonists migraine ... See more keywords
Calcitonin gene‐related peptide: An intra‐articular therapeutic target for TMJ disorders
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.606
Abstract: The goal of this project was to evaluate the role of calcitonin gene‐related peptide (CGRP) in the development of arthritis. read more here.
Keywords: calcitonin gene; related peptide; intra articular; peptide intra ... See more keywords
Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_173
Abstract: The calcitonin gene-related peptide (CGRP) receptor is composed of the calcitonin receptor-like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as receptor activity modifying protein type 1 (RAMP1). The levels of… read more here.
Keywords: cgrp; related peptide; gene related; calcitonin gene ... See more keywords
An Intraperitoneal Treatment with Calcitonin Gene-Related Peptide (CGRP) Regulates Appetite, Energy Intake/Expenditure, and Metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1202-3
Abstract: Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide expressed both centrally and peripherally. CGRP has been shown to be involved in arteriolar dilation, cardiovascular regulation, pain transmission, migraine, and gastrointestinal physiology. Our current research… read more here.
Keywords: energy; cgrp; metabolism; treatment ... See more keywords
A new era for migraine: The role of calcitonin gene-related peptide in the trigeminovascular system.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2020.05.012
Abstract: There is a huge improvement in our understanding of migraine pathophysiology in the past decades. The activation of the trigeminovascular system has been proved to play a key role in migraine. Calcitonin gene-related peptide (CGRP)… read more here.
Keywords: migraine; trigeminovascular system; cgrp; gene related ... See more keywords
Calcitonin gene-related peptide (CGRP)-targeted therapies as preventive and acute treatments for migraine-The monoclonal antibodies and gepants.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2020.06.019
Abstract: Calcitonin Gene-Related Peptide (CGRP) plays a pivotal role in migraine pathophysiology. Two types of CGRP function-blocking modalities, monoclonal antibodies, and small molecules (gepants), have been developed to target the CGRP ligands and CGRP receptors. Four… read more here.
Keywords: monoclonal antibodies; cgrp; related peptide; gene related ... See more keywords
Secretoneurin and PE-11 immunoreactivity in the human dental pulp.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.11.005
Abstract: OBJECTIVE To explore whether there are differences in the concentration of the secretogranin II-derived peptide secretoneurin and the chromogranin B-derived peptide PE-11 between the healthy and inflamed human dental pulps. Furthermore, colocalization studies with calcitonin… read more here.
Keywords: secretoneurin; human dental; gene related; calcitonin gene ... See more keywords
α−Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.06.024
Abstract: Objective Although it is well established that a-calcitonin gene-related peptide (CGRP) stabilizes muscle-type cholinergic receptors nicotinic subunits (AChR), the underlying mechanism by which this neuropeptide regulates muscle protein metabolism and neuromuscular junction (NMJ) morphology is… read more here.
Keywords: autophagy calpain; related peptide; gene related; calcitonin gene ... See more keywords