Cell active and functionally-relevant small-molecule agonists of calcitonin receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103596
Abstract: The natural calcitonin (CT) receptor and its peptide agonists are considered validated targets for drug discovery. A small molecule agonist, SUN-B8155, has previously been shown to efficiently activate cellular CTR. Herein, we report the synthesis… read more here.
Keywords: receptor; small molecule; cell active; calcitonin receptor ... See more keywords
An amylin and calcitonin receptor agonist modulates alcohol behaviors by acting on reward-related areas in the brain
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2020.101969
Abstract: Alcohol causes stimulatory behavioral responses by activating reward-processing brain areas including the laterodorsal (LDTg) and ventral tegmental areas (VTA) and the nucleus accumbens (NAc). Systemic administration of the amylin and calcitonin receptor agonist salmon calcitonin… read more here.
Keywords: calcitonin receptor; amylin calcitonin; receptor agonist; sct ... See more keywords
Adrenomedullin 2 and 5 activate the calcitonin receptor-like receptor (clr) - receptor activity-modifying protein 3 (ramp3) receptor complex in Xenopus tropicalis.
Sign Up to like & getrecommendations! Published in 2021 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2021.113752
Abstract: The adrenomedullin (AM) family is involved in diverse biological functions, including cardiovascular regulation and body fluid homeostasis, in multiple vertebrate lineages. The AM family consists of AM1, AM2, and AM5 in tetrapods, and the receptor… read more here.
Keywords: calcitonin receptor; like receptor; receptor like; clr ... See more keywords
Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28131-z
Abstract: Social animals actively engage in contact with conspecifics and experience stress upon isolation. However, the neural mechanisms coordinating the sensing and seeking of social contacts are unclear. Here we report that amylin-calcitonin receptor (Calcr) signaling… read more here.
Keywords: amylin calcitonin; calcitonin receptor; amylin; preoptic area ... See more keywords
Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92465
Abstract: Lymphatics play a critical role in maintaining gastrointestinal homeostasis and in the absorption of dietary lipids, yet their roles in intestinal inflammation remain elusive. Given the increasing prevalence of inflammatory bowel disease, we investigated whether… read more here.
Keywords: calcitonin receptor; intestinal inflammation; inflammation; like receptor ... See more keywords
Calcitonin receptor antibody validation and expression in the rodent brain
Sign Up to like & getrecommendations! Published in 2022 at "Cephalalgia"
DOI: 10.1177/03331024221084029
Abstract: Background and aim Therapeutics that reduce calcitonin gene-related peptide activity are effective migraine treatments. However, gaps remain in our understanding of the molecular mechanisms that link calcitonin gene-related peptide to migraine. The amylin 1 receptor… read more here.
Keywords: receptor; rodent brain; calcitonin receptor; related peptide ... See more keywords
Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.72845.1
Abstract: The expression of the calcitonin receptor (CT Receptor) is widespread throughout the life cycle of mammals and in many diseases, and in these contexts the functions of the common isoforms is largely unknown. The relatively… read more here.
Keywords: calcitonin receptor; apoptosis; receptor; cell ... See more keywords
Mouse Microglial Calcitonin Receptor Knockout Impairs Hypothalamic Amylin Neuronal pSTAT3 Signaling but Lacks Major Metabolic Consequences
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12010051
Abstract: Amylin and leptin synergistically interact in the arcuate nucleus of the hypothalamus (ARC) to control energy homeostasis. Our previous rodent studies suggested that amylin-induced interleukin-6 release from hypothalamic microglia may modulate leptin signaling in agouti-related… read more here.
Keywords: pstat3; microglial calcitonin; calcitonin receptor; mice ... See more keywords