Heck- and Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase
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DOI: 10.3762/bjoc.15.94
Abstract: In this study, we explored Heck- and Suzuki-coupling methodology to modify the template 2,5-di-tert-butylhydroquinone (BHQ, 2), an inhibitor of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA). We found that by utilizing Suzuki coupling, we could… read more here.
Keywords: suzuki coupling; calcium atpase; suzuki; coupling approaches ... See more keywords
Intracoronary Sarcoplasmic Reticulum Calcium-ATPase Gene Therapy in Advanced Heart Failure Patients with reduced Ejection Fraction: A Prospective Cohort Study
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DOI: 10.6061/clinics/2020/e1530
Abstract: OBJECTIVE: Heart failure is a progressive and debilitating disease. Intracoronary sarcoplasmic reticulum calcium-ATPase gene therapy may improve the function of cardiac muscle cells. This study aimed to test the hypothesis that intracoronary sarcoplasmic reticulum calcium-ATPase… read more here.
Keywords: gene therapy; calcium atpase; sarcoplasmic reticulum; atpase gene ... See more keywords