Kalirin mediates Rac1 activation downstream of calcium/calmodulin‐dependent protein kinase II to stimulate glucose uptake during muscle contraction
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14428
Abstract: In this study, we investigated the role of calcium/calmodulin‐dependent protein kinase II (CaMKII) in contraction‐stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to… read more here.
Keywords: contraction; muscle; kinase; calcium calmodulin ... See more keywords
Regulation of Multifunctional Calcium/Calmodulin Stimulated Protein Kinases by Molecular Targeting.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_26
Abstract: Multifunctional calcium/calmodulin-stimulated protein kinases control a broad range of cellular functions in a multitude of cell types. This family of kinases contain several structural similarities and all are regulated by phosphorylation, which either activates, inhibits… read more here.
Keywords: multifunctional calcium; protein kinases; calmodulin stimulated; molecular targeting ... See more keywords
Induced effect of Ca2+ on dalesconols A and B biosynthesis in the culture of Daldinia eschscholzii via calcium/calmodulin signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2017.08.018
Abstract: Dalesconols (dalesconols A and B) were isolated from Daldinia eschscholzii and have remarkable immunosuppressive activity. In this study, the response of fungal growth, intra- and extracellular Ca2+, and dalesconols production after CaCl2 addition were reported… read more here.
Keywords: dalesconols biosynthesis; calmodulin signaling; ca2; calcium calmodulin ... See more keywords
Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00008
Abstract: Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. We showed previously that calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), a serine-threonine kinase, is highly expressed in gastric… read more here.
Keywords: protein; gastric cancer; calmodulin dependent; kinase ... See more keywords
Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82067-w
Abstract: WNT ligands can activate several signalling cascades of pivotal importance during development and regenerative processes. Their de-regulation has been associated with the onset of different diseases. Here we investigated the role of the WNT/Calcium Calmodulin… read more here.
Keywords: calcium calmodulin; calmodulin kinase; camkii; osteoarthritis ... See more keywords
Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1911452116
Abstract: Significance The structural dynamics of the dendritic synapse, arising from the remodeling of actin cytoskeletons, has been widely associated with memory and cognition. The remodeling is regulated by intracellular Ca2+ levels. Under low Ca2+ concentration,… read more here.
Keywords: actin; calcium calmodulin; camkii; dendritic spines ... See more keywords
High throughput screening, docking, and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1479310
Abstract: Abstract Calcium/calmodulin-dependent protein kinase IV (CAMKIV) is associated with many diseases including cancer and neurodegenerative disorders and thus being considered as a potential drug target. Here, we have employed the knowledge of three-dimensional structure of… read more here.
Keywords: protein; calmodulin dependent; kinase; dependent protein ... See more keywords
Inhibition of calcium/calmodulin-dependent protein kinase IV in arthritis: Dual effect on Th17 cell activation and osteoclastogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac381
Abstract: OBJECTIVE To investigate the role of calcium/calmodulin-dependent protein kinase IV (CaMK4) in the development of joint injury in a mouse model of arthritis and patients with rheumatoid arthritis (RA). METHODS Camk4-deficient, Camk4flox/floxLck-Cre, and mice treated… read more here.
Keywords: cell; inhibition; th17; arthritis ... See more keywords
Calcium‐/calmodulin‐dependent protein kinase II in occlusion‐induced degenerative cartilage of rat mandibular condyle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Oral Rehabilitation"
DOI: 10.1111/joor.12629
Abstract: Activated calcium-/calmodulin-dependent protein kinaseII (CaMKII) is important to promote chondrocytes from proliferative to pre-hypertrophic state, which probably plays a role in osteoarthritis (OA), a widespread degeneration disease with enhanced aberrant chondrocyte differentiation. Our aim was… read more here.
Keywords: protein; calmodulin dependent; dependent protein; camkii ... See more keywords
Calcium/Calmodulin-Dependent Kinases in the Hypothalamus, Pituitary, and Pineal Gland: An Overview
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/1103346
Abstract: We review the literature on the little-known roles of specific CaMKs in regulating endocrine functions of the pineal gland, the pituitary gland, and the hypothalamus. Melatonin activates hippocampal CaMKII, which then influences dendritogenesis. In the… read more here.
Keywords: calmodulin dependent; kinases hypothalamus; pineal gland; gland ... See more keywords
p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.759259
Abstract: p21-Activated kinase-1 (Pak1) is frequently overexpressed and/or amplified in human breast cancer and is necessary for transformation of mammary epithelial cells. Here, we show that Pak1 interacts with and phosphorylates the Calcium/Calmodulin-dependent Protein Kinase II… read more here.
Keywords: activated kinase; kinase; breast cancer; calcium calmodulin ... See more keywords