Evaluation of in vitro effect, molecular docking, and molecular dynamics simulations of some dihydropyridine-class calcium channel blockers on human serum paraoxonase 1 (hPON1) enzyme activity.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2467
Abstract: Paraoxonase 1 (PON1) was purified 148.80-fold in 37.92% yield by hydrophobic interaction chromatography technique. The purity of PON1 was checked by SDS PAGE with a single band of 43 kDa. The in vitro effects of… read more here.
Keywords: molecular docking; channel blockers; calcium channel; molecular dynamics ... See more keywords
Chiral separation of calcium channel antagonists by SFC and HPLC using different immobilized chiral stationary phases.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23410
Abstract: Supercritical fluid chromatography and high-performance liquid chromatography techniques are popular for the chiral separations of different drugs and pharmaceuticals. Therefore, this article describes a comparative study of the chiral separation of some calcium channel antagonists… read more here.
Keywords: separation calcium; channel antagonists; calcium channel; chiral separation ... See more keywords
Hair analysis for beta‐blockers and calcium‐channel blockers by using liquid chromatography‐tandem mass spectrometry as a tool for monitoring adherence to antihypertensive therapy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3346
Abstract: Abstract Adherence to therapy is the key to a successful therapeutic intervention, especially in cardiovascular diseases in which a lack of adherence may have serious consequences in terms morbidity and/or mortality. In this context, hair… read more here.
Keywords: adherence; channel blockers; calcium channel; therapy ... See more keywords
Synergistic antinociception between ZC88, an N‐type voltage‐dependent calcium channel blocker, and ibuprofen in mouse models of visceral and somatic inflammatory pain
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pain"
DOI: 10.1002/ejp.1281
Abstract: A combination of analgesic agents with different mechanisms can induce additive or synergistic analgesia. The N‐type voltage‐dependent calcium channel (N‐VDCC) is a novel therapeutic target for pain control. In addition to providing effective pain relief… read more here.
Keywords: type voltage; calcium channel; dependent calcium; voltage dependent ... See more keywords
L-type calcium channel blockers and a symptom complex mimicking de Melo-Souza’s syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Neurological Sciences"
DOI: 10.1007/s10072-018-3662-1
Abstract: Dear Editor, Drugs are an important cause of tremor in the elderly and the second most common cause of Parkinsonism. Common medications which induce tremor include salbutamol, theophylline, valproate, anti-depressants, anti-psychotics, and anti-dopaminergics [1, 2].… read more here.
Keywords: calcium channel; melo souza; type calcium; channel blockers ... See more keywords
Neuroprotective Effects of Early Brain Injury after Subarachnoid Hemorrhage in Rats by Calcium Channel Mediating Hydrogen Sulfide
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00940-0
Abstract: The present study explored the modulating apoptosis effect of hydrogen sulfide (H2S) in subarachnoid hemorrhage (SAH) rats and its exact mechanism. A rat SAH model established by intravascular puncturing was used for the present study.… read more here.
Keywords: calcium channel; sah nahs; group; subarachnoid hemorrhage ... See more keywords
Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-8273-8
Abstract: A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and… read more here.
Keywords: synthesis dihydropyridine; synthesis; calcium channel; papain catalyzed ... See more keywords
CatSper: A Unique Calcium Channel of the Sperm Flagellum.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in physiology"
DOI: 10.1016/j.cophys.2018.02.004
Abstract: To overcome egg protective vestments and ensure successful fertilization, mammalian spermatozoa switch symmetrical progressive motility to a powerful, whip-like flagellar motion, known as hyperactivation. The latter is triggered by a calcium influx through the sperm-specific,… read more here.
Keywords: catsper; calcium channel; channel; channel sperm ... See more keywords
Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.032
Abstract: Nifedipine and isradipine are prominent examples of calcium channel blockers with a 1,4-dihydropyridine (DHP) scaffold. Although successfully used in clinics since decades for the treatment of hypertension, the binding mechanism to their target, the L-type… read more here.
Keywords: novel; calcium channel; binding mechanism; channel ... See more keywords
Ferulic acid relaxed rat aortic, small mesenteric and coronary arteries by blocking voltage‐gated calcium channel and calcium desensitization via dephosphorylation of ERK1/2 and MYPT1
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.10.008
Abstract: Abstract Ferulic acid, a natural ingredient presents in several Chinese Materia Medica such as Radix Angelicae Sinensis, has been identified as an important multifunctional and physiologically active small molecule. However, its pharmacological activity in different… read more here.
Keywords: calcium channel; coronary arteries; via dephosphorylation; ferulic acid ... See more keywords
M102 VARIATION IN VOLTAGE-GATED CALCIUM CHANNEL GENES IS ASSOCIATED WITH ANTIPSYCHOTIC TREATMENT RESPONSE IN A SOUTH AFRICAN FIRST EPISODE SCHIZOPHRENIA COHORT
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.409
Abstract: Background Voltage-gated calcium channels have been implicated in schizophrenia aetiology, however little is known about their involvement in antipsychotic treatment response. This study investigated variants within the calcium channel subunit genes for association with antipsychotic… read more here.
Keywords: treatment response; calcium channel; treatment; south african ... See more keywords