Synergistic effect of electromagnetic fields and nanomagnetic particles on osteogenesis through calcium channels and p‐ERK signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.24905
Abstract: Electromagnetic fields (EMFs) are widely used in a number of cell therapies and bone disorder treatments, and nanomagnetic particles (NMPs) also promote cell activity. In this study, we investigated the synergistic effects of EMFs and… read more here.
Keywords: electromagnetic fields; calcium channels; calcium; cell ... See more keywords
Skeletal Functions of Voltage Sensitive Calcium Channels
Sign Up to like & getrecommendations! Published in 2021 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-020-00647-7
Abstract: Voltage-sensitive calcium channels (VSCCs) are ubiquitous multimeric protein complexes that are necessary for the regulation of numerous physiological processes. VSCCs regulate calcium influx and various intracellular processes including muscle contraction, neurotransmission, hormone secretion, and gene… read more here.
Keywords: sensitive calcium; calcium channels; functions vsccs; bone ... See more keywords
Trimethyltin Increases Intracellular Ca2+ Via L-Type Voltage-Gated Calcium Channels and Promotes Inflammatory Phenotype in Rat Astrocytes In Vitro
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02273-x
Abstract: Astrocytes are the first responders to noxious stimuli by undergoing cellular and functional transition referred as reactive gliosis. Every acute or chronic disorder is accompanied by reactive gliosis, which could be categorized as detrimental (A1)… read more here.
Keywords: tmt induced; type voltage; calcium channels; gated calcium ... See more keywords
Discovery of Michael acceptor containing 1,4-dihydropyridines as first covalent inhibitors of L-/T-type calcium channels.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103187
Abstract: 1,4-Dihydropyridines (DHPs) are an important class of blockers targeting different calcium channel subtypes and have great therapeutic value against cardiovascular and neurophysiologic conditions. Here, we present the design of DHP-based hexahydroquinoline derivatives as either selective… read more here.
Keywords: covalent inhibitors; calcium channels; type calcium; michael acceptor ... See more keywords
Splice-variant-specific effects of primary aldosteronism point mutations on human CaV3.2 calcium channels.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.102104
Abstract: CaV3.2 calcium channels play important roles in both neural excitability and aldosterone secretion. Recent clinical studies found four germline mutations (S196 L, M1549I, V1951E and P2083 L) in CaV3.2 channels. All four mutations caused primary aldosteronism (PA),… read more here.
Keywords: splice; calcium channels; cav3 channels; cav3 calcium ... See more keywords
RyR2 calcium channels in the spotlight-I'm ready for my close up, Dr. Alzheimer!
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2020.102342
Abstract: While various hypotheses surrounding the etiology of Alzheimer's disease (AD) have waxed and waned over the years, the calcium hypothesis of aging [1] has maintained its steady trajectory since the early 1990's, albeit often as… read more here.
Keywords: ready close; calcium channels; spotlight ready; ryr2 calcium ... See more keywords
Cannabidiol selectively inhibits the contraction of rat small resistance arteries: possible role for CGRP and voltage-gated calcium channels.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173767
Abstract: The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes more widely prescribed. This study aimed to examine the effects of cannabidiol on a wide range of… read more here.
Keywords: resistance arteries; calcium channels; small resistance; pharmacology ... See more keywords
Role of voltage-gated calcium channels on striatal dopamine release induced by inorganic mercury in freely moving rats.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2018.02.005
Abstract: The possible role of voltage-sensitive calcium channels (VSCC) activation on the HgCl2-induced dopamine release was investigated using selective VSCC blockers and the dopamine levels were measured by HPLC from samples obtained by in vivo brain… read more here.
Keywords: dopamine release; calcium channels; role voltage; release induced ... See more keywords
Analysis of tetrodotoxin-sensitive sodium and low voltage-activated calcium channels in developing mouse retinal horizontal cells.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108028
Abstract: Expression patterns of voltage-gated ion channels determine the spatio-temporal dynamics of ion currents that supply excitable neurons in developing tissue with proper electrophysiological properties. The purpose of the study was to identify fast cationic inward… read more here.
Keywords: voltage; sensitive sodium; calcium channels; type calcium ... See more keywords
Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112039
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Parsley (Petroselinum crispum; P. crispum) is among the popular aromatic vegetables and a part of the daily diet in the Mediterranean area. This plant is widely used in alternative medicine as a remedy… read more here.
Keywords: calcium channels; antihypertensive activity; petroselinum crispum; crispum ... See more keywords
Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.06.018
Abstract: The synaptic adhesion molecules Neurexin and Neuroligin alter the development and function of synapses and are linked to autism in humans. In C. elegans, post-synaptic Neurexin (NRX-1) and pre-synaptic Neuroligin (NLG-1) mediate a retrograde synaptic signal… read more here.
Keywords: neurexin binding; calcium channels; retrograde synaptic; inhibition mediated ... See more keywords