In silico Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.755881
Abstract: Myocardial delivery of human c-kit+ cardiac interstitial cells (hCICs) and human mesenchymal stem cells (hMSCs), an emerging approach for treating the failing heart, has been limited by an incomplete understanding of the effects on host… read more here.
Keywords: cell; calcium; electrophysiology calcium; calcium cycling ... See more keywords
Modeling Calcium Cycling in the Heart: Progress, Pitfalls, and Challenges
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DOI: 10.3390/biom12111686
Abstract: Intracellular calcium (Ca) cycling in the heart plays key roles in excitation–contraction coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, i.e., the ryanodine receptors (RyRs), are clustered in the sarcoplasmic reticulum membrane, forming… read more here.
Keywords: calcium cycling; cycling heart; modeling calcium; progress ... See more keywords