Deacylation of Calcium‐Dependent Antibiotics from Streptomyces violaceoruber in Co‐culture with Streptomyces sp. MG7‐G1
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000404
Abstract: When Streptomyces violaceoruber grows together with Streptomyces sp. MG7‐G1, it reacts with strongly induced droplet production on its aerial mycelium. Initially the metabolite profile of droplets from S. violaceoruber in co‐culture with Streptomyces sp. MG7‐G1… read more here.
Keywords: dependent antibiotics; calcium dependent; streptomyces violaceoruber; culture ... See more keywords
Rapeseed calcium-dependent protein kinase CPK6L modulates reactive oxygen species and cell death through interacting and phosphorylating RBOHD.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.118
Abstract: Reactive oxygen species (ROS) play important roles in plant growth, development, responses to abiotic and biotic stresses. Hypersensitive response (HR)-like cell death is often associated with excess ROS. However, how a calcium-dependent protein kinase (CPK)… read more here.
Keywords: protein; reactive oxygen; death; calcium dependent ... See more keywords
The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2021.07.003
Abstract: Calpains are evolutionarily conserved and widely expressed Ca2+-activated cysteine proteases that act at neutral pH. The activity of calpains is tightly regulated, given that their abnormal activation can have deleterious effects leading to promiscuous cleavage… read more here.
Keywords: calcium dependent; calpain neuronal; neurodegeneration; protease calpain ... See more keywords
The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology"
DOI: 10.1017/s0031182017001901
Abstract: Summary The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique… read more here.
Keywords: calcium dependent; dependent protein; gondii; structure based ... See more keywords
Antibacterial drugs: Discovering antibiotics through soil metagenomics
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2018.36
Abstract: products with antimicrobial properties has been hampered by the fact that many bacteria cannot be cultured in the laboratory, and those that can do not produce all of their natural products in this setting. Hover… read more here.
Keywords: calcium dependent; natural products; adenylation; calcium ... See more keywords
STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1715997115
Abstract: Significance Association of the adaptor protein STAC3 to the calcium channel was recently identified as essential for skeletal muscle contraction. While STAC3 is expressed exclusively in skeletal muscle, the other two isoforms, STAC1 and STAC2,… read more here.
Keywords: stac proteins; calcium dependent; cav1; domain ... See more keywords
In-silico analysis of Calcium Dependent Protein Kinase 6 of Cryptosporidium parvum through molecular modeling, docking, and dynamics simulation study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1790036
Abstract: Abstract Calcium Dependent Protein Kinases are found in the Apicomplexan, algae, and plants; however, they are not reported in vertebrates and are regarded as excellent drug targets for pharmaceutical interventions. Calcium Dependent Protein Kinases of… read more here.
Keywords: dependent protein; calcium dependent; study; protein kinase ... See more keywords
Anthrax protective antigen is a calcium-dependent serine protease
Sign Up to like & getrecommendations! Published in 2018 at "Virulence"
DOI: 10.1080/21505594.2018.1486139
Abstract: ABSTRACT Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that… read more here.
Keywords: calcium dependent; serine protease; protective antigen; dependent serine ... See more keywords
Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.12.08.519572
Abstract: Nociceptive habituation is a conserved process through which pain-sensitivity threshold is adjusted based on past sensory experience and which may be dysregulated in human chronic pain conditions. Noxious heat habituation in C. elegans involves the… read more here.
Keywords: localization; cmk; cam; calcium dependent ... See more keywords
Functional Consequences of Calcium-Dependent Synapse-to-Nucleus Communication: Focus on Transcription-Dependent Metabolic Plasticity.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a035287
Abstract: In the nervous system, calcium signals play a major role in the conversion of synaptic stimuli into transcriptional responses. Signal-regulated gene transcription is fundamental for a range of long-lasting adaptive brain functions that include learning… read more here.
Keywords: transcription; calcium dependent; synapse nucleus; calcium ... See more keywords
A Tale of Two Isoforms: Calcium-Dependent Inhibition of SnRK2 by SnRK-Calcium-Binding Sensor
Sign Up to like & getrecommendations! Published in 2020 at "Plant Physiology"
DOI: 10.1104/pp.19.01554
Abstract: Reacting to the environment requires not only activating signaling cascades but also modulating the activity of individual components in a context- and time-dependent manner. For example, under nonstress conditions, protein phosphatases 2C (PP2C) keep the… read more here.
Keywords: calcium dependent; tale two; two isoforms; isoforms calcium ... See more keywords