Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004389
Abstract: Background: Long-lasting local anesthetic use for perioperative pain control is limited by possible cardiotoxicity (e.g., arrhythmias and contractile depression), potentially leading to cardiac arrest. Off-target cardiac sodium channel blockade is considered the canonical mechanism behind… read more here.
Keywords: calcium dynamics; calcium; toxicity; cardiotoxicity ... See more keywords
Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons
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DOI: 10.1111/ejn.13287
Abstract: The striatum is a major site of learning and memory formation for sensorimotor and cognitive association. One of the mechanisms used by the brain for memory storage is synaptic plasticity – the long‐lasting, activity‐dependent change… read more here.
Keywords: direction synaptic; calcium dynamics; calcium; synaptic plasticity ... See more keywords
Long-Term Oral Administration of Theaphenon-E Improves Cardiomyocyte Mechanics and Calcium Dynamics by Affecting Phospholamban Phosphorylation and ATP Production
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000490219
Abstract: Background/Aims: Dietary polyphenols from green tea have been shown to possess cardio-protective activities in different experimental models of heart diseases and age-related ventricular dysfunction. The present study was aimed at evaluating whether long term in… read more here.
Keywords: administration; long term; calcium dynamics; calcium ... See more keywords
Beta-Cell Adaptation to Pregnancy – Role of Calcium Dynamics
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DOI: 10.3389/fendo.2022.853876
Abstract: During pregnancy, the mother develops insulin resistance to shunt nutrients to the growing fetus. As a result, the maternal islets of Langerhans undergo several changes to increase insulin secretion in order to maintain glucose homeostasis… read more here.
Keywords: calcium dynamics; calcium; cell; insulin secretion ... See more keywords
Glucose-Stimulated Calcium Dynamics in Beta Cells From Male C57BL/6J, C57BL/6N, and NMRI Mice: A Comparison of Activation, Activity, and Deactivation Properties in Tissue Slices
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DOI: 10.3389/fendo.2022.867663
Abstract: Although mice are a very instrumental model in islet beta cell research, possible phenotypic differences between strains and substrains are largely neglected in the scientific community. In this study, we show important phenotypic differences in… read more here.
Keywords: calcium dynamics; beta cell; c57bl c57bl; tissue slices ... See more keywords
High-speed 2D light-sheet fluorescence microscopy enables quantification of spatially varying calcium dynamics in ventricular cardiomyocytes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1079727
Abstract: Introduction: Reduced synchrony of calcium release and t-tubule structure organization in individual cardiomyocytes has been linked to loss of contractile strength and arrhythmia. Compared to confocal scanning techniques widely used for imaging calcium dynamics in… read more here.
Keywords: calcium dynamics; light sheet; calcium; microscopy ... See more keywords
Novel Algorithm of Network Calcium Dynamics Analysis for Studying the Role of Astrocytes in Neuronal Activity in Alzheimer’s Disease Models
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DOI: 10.3390/ijms232415928
Abstract: Accumulated experimental data strongly suggest that astrocytes play an important role in the pathogenesis of neurodegeneration, including Alzheimer’s disease (AD). The effect of astrocytes on the calcium activity of neuron–astroglia networks in AD modelling was… read more here.
Keywords: calcium dynamics; calcium; alzheimer disease; activity ... See more keywords