Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15917
Abstract: Increasing evidence suggests that astrocytes play an important role in the progression of Parkinson's disease (PD). Previous studies on our parkin knockout mouse demonstrated a higher accumulation of damaged mitochondria in astrocytes than in surrounding… read more here.
Keywords: loss parkin; endoplasmic reticulum; calcium dyshomeostasis; parkin ... See more keywords
Huntington’s Disease: Calcium Dyshomeostasis and Pathology Models
Sign Up to like & getrecommendations! Published in 2017 at "Acta Naturae"
DOI: 10.32607/20758251-2017-9-2-34-46
Abstract: Huntington’s disease (HD) is a severe inherited neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and mental impairment. At the molecular level, HD is caused by a mutation in the first exon of the gene… read more here.
Keywords: huntington disease; calcium dyshomeostasis; disease; pathology ... See more keywords
Calcium Dyshomeostasis in Alzheimer’s Disease Pathogenesis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094914
Abstract: Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder that is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles consisting of abnormally phosphorylated tau protein, and neuronal loss leading to cognitive decline… read more here.
Keywords: disease pathogenesis; alzheimer disease; calcium dyshomeostasis; dyshomeostasis alzheimer ... See more keywords