Store-Operated Calcium Entry in Mouse Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04516-x
Abstract: The fluorescent dye fura-2 AM was employed to record activation of Ca2+ entry in response to a decrease in Ca2+ concentration in the endoplasmic reticulum. Using whole-cell voltage clamp technique, we revealed Ca2+ currents with… read more here.
Keywords: store operated; calcium entry; entry mouse; entry ... See more keywords
Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1290-7
Abstract: Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7q11.23) are neurodevelopmental disorders caused by the deletion and duplication, respectively, of ~ 25 protein-coding genes on chromosome 7q11.23. The general transcription factor 2I (GTF2I, protein TFII-I) is one… read more here.
Keywords: transcription factor; trpc3; calcium entry; factor regulates ... See more keywords
Proteolytically Activated CRAC Effectors through Designed Intramolecular Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00151
Abstract: Highly regulated intracellular calcium entry affects numerous cellular physiological events. External regulation of intracellular calcium signaling presents a great opportunity for the artificial regulation of cellular activity. Calcium entry can be mediated by STIM proteins… read more here.
Keywords: calcium; protease; calcium entry; pace ... See more keywords
Corrigendum: The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/srep47002
Abstract: This corrects the article DOI: 10.1038/srep37196. read more here.
Keywords: corrigendum neuroprotective; apoptosis calcium; calcium entry; dexmedetomidine apoptosis ... See more keywords
Force- and cell state–dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo1461
Abstract: Mechanosensing is an integral part of many physiological processes including stem cell differentiation, fibrosis, and cancer progression. Two major mechanosensing systems—focal adhesions and mechanosensitive ion channels—can convert mechanical features of the microenvironment into biochemical signals.… read more here.
Keywords: cell; dynamics calcium; calcium entry; adhesion dynamics ... See more keywords
Abstract C045: RP4010, a small molecule inhibitor of Store-Operated Calcium Entry (SOCE), potentiates activity of Gilteritinib and Cytarabine in preclinical models of AML
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c045
Abstract: Background: Store-operated calcium entry (SOCE) through calcium release activated calcium (CRAC) channels contribute to calcium influx in non-excitable cells. Elevation of cytosolic calcium through SOCE mediates an array of cellular responses including metabolism and gene… read more here.
Keywords: soce; operated calcium; calcium entry; activity ... See more keywords
Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the Cacna2d4 Mouse Model of Cone-Rod Dystrophy RCD4
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113080
Abstract: Unidentified pathogenetic mechanisms and genetic and clinical heterogeneity represent critical factors hindering the development of treatments for inherited retinal dystrophies. Frameshift mutations in Cacna2d4, which codes for an accessory subunit of voltage-gated calcium channels (VGCC),… read more here.
Keywords: calcium; calcium stores; cone rod; calcium entry ... See more keywords
Searching for Mechanisms Underlying the Assembly of Calcium Entry Units: The Role of Temperature and pH
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065328
Abstract: Store-operated Ca2+ entry (SOCE) is a mechanism that allows muscle fibers to recover external Ca2+, which first enters the cytoplasm and then, via SERCA pump, also refills the depleted intracellular stores (i.e., the sarcoplasmic reticulum,… read more here.
Keywords: edl muscles; entry; temperature; calcium entry ... See more keywords
Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.77696
Abstract: The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function. We developed C17, a potent small-molecule DYRK2… read more here.
Keywords: dyrk2; selective inhibition; calcium entry; function ... See more keywords