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Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04516-x
Abstract: The fluorescent dye fura-2 AM was employed to record activation of Ca2+ entry in response to a decrease in Ca2+ concentration in the endoplasmic reticulum. Using whole-cell voltage clamp technique, we revealed Ca2+ currents with…
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Keywords:
store operated;
calcium entry;
entry mouse;
entry ... See more keywords
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Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1290-7
Abstract: Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7q11.23) are neurodevelopmental disorders caused by the deletion and duplication, respectively, of ~ 25 protein-coding genes on chromosome 7q11.23. The general transcription factor 2I (GTF2I, protein TFII-I) is one…
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Keywords:
transcription factor;
trpc3;
calcium entry;
factor regulates ... See more keywords
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Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00151
Abstract: Highly regulated intracellular calcium entry affects numerous cellular physiological events. External regulation of intracellular calcium signaling presents a great opportunity for the artificial regulation of cellular activity. Calcium entry can be mediated by STIM proteins…
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Keywords:
calcium;
protease;
calcium entry;
pace ... See more keywords
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Published in 2018 at "Scientific Reports"
DOI: 10.1038/srep47002
Abstract: This corrects the article DOI: 10.1038/srep37196.
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Keywords:
corrigendum neuroprotective;
apoptosis calcium;
calcium entry;
dexmedetomidine apoptosis ... See more keywords
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Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo1461
Abstract: Mechanosensing is an integral part of many physiological processes including stem cell differentiation, fibrosis, and cancer progression. Two major mechanosensing systems—focal adhesions and mechanosensitive ion channels—can convert mechanical features of the microenvironment into biochemical signals.…
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Keywords:
cell;
dynamics calcium;
calcium entry;
adhesion dynamics ... See more keywords
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Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c045
Abstract: Background: Store-operated calcium entry (SOCE) through calcium release activated calcium (CRAC) channels contribute to calcium influx in non-excitable cells. Elevation of cytosolic calcium through SOCE mediates an array of cellular responses including metabolism and gene…
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Keywords:
soce;
operated calcium;
calcium entry;
activity ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113080
Abstract: Unidentified pathogenetic mechanisms and genetic and clinical heterogeneity represent critical factors hindering the development of treatments for inherited retinal dystrophies. Frameshift mutations in Cacna2d4, which codes for an accessory subunit of voltage-gated calcium channels (VGCC),…
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Keywords:
calcium;
calcium stores;
cone rod;
calcium entry ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065328
Abstract: Store-operated Ca2+ entry (SOCE) is a mechanism that allows muscle fibers to recover external Ca2+, which first enters the cytoplasm and then, via SERCA pump, also refills the depleted intracellular stores (i.e., the sarcoplasmic reticulum,…
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Keywords:
edl muscles;
entry;
temperature;
calcium entry ... See more keywords
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Published in 2022 at "eLife"
DOI: 10.7554/elife.77696
Abstract: The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function. We developed C17, a potent small-molecule DYRK2…
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Keywords:
dyrk2;
selective inhibition;
calcium entry;
function ... See more keywords