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Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.05.096
Abstract: The detection and classification of proarrhythmic phenotypes like early afterdepolarizations (EADs) is fundamental in the safety pharmacology assessment of developing drugs. Calcium flux analysis enables sensitive and high throughput in vitro assays to assess potential…
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Keywords:
early afterdepolarizations;
calcium flux;
calcium;
classification ... See more keywords
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Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c05626
Abstract: Electrophysiological measurement of molecular translocation through a nanopore is the fundamental basis of nanopore sensing. Free translocation of nucleic acids however is normally so fast that the identities of the compounds are not clearly resolvable.…
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Keywords:
nucleic acids;
nanopore sensing;
translocation;
translocation nucleic ... See more keywords
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Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa140.mo059
Abstract: The global increase in opioid use requires practitioners to be aware of the side effects and contraindications of these medications in order to avoid complications, especially in patients with organ dysfunction such as cardiovascular disease…
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Keywords:
brl52537;
application;
hypertension;
calcium ... See more keywords
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Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21207652
Abstract: We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca+2 channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl…
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Keywords:
cholinesterases calcium;
synthesis hantzsch;
hantzsch adducts;
flux inhibitors ... See more keywords