The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism, and bone health in uremic rats
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1586883
Abstract: ABSTRACT Background: Klotho is a key regulator of phosphate and Ca2+-transport in the kidney. Recently, we showed that treatment with LP533401 improved bone health in rats with chronic kidney disease (CKD) via the normalization of… read more here.
Keywords: uremic rats; renal calcium; calcium handling; bone health ... See more keywords
Sulforaphane Effects on Cardiac Function and Calcium-Handling–Related Proteins in 2 Experimental Models of Heart Disease: Ischemia-Reperfusion and Infarction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001191
Abstract: Abstract: Sulforaphane (SFN) is a natural exogenous antioxidant from cruciferous vegetables already shown to improve cardiac function in cardiovascular diseases. The aim of this study was to analyze the effect of SFN treatment on the… read more here.
Keywords: cardiac function; ischemia; calcium handling; sfn ... See more keywords
Thyroid hormone disorder and the heart: The role of cardiolipin in calcium handling
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Physiology"
DOI: 10.1113/ep090817
Abstract: What is the central question of this study? Do alterations in thyroid status affect haemodynamic parameters and echocardiographic measurements in the rat postnatal heart, and calcium handling, contractility, relaxation and cardiolipin content in isolated rat… read more here.
Keywords: calcium handling; cardiolipin; thyroid hormone; hormone disorder ... See more keywords
Abstract 339: Biomechanics and Calcium Handling of Thin Filament Hypertrophic Cardiomyopathy Variants
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.339
Abstract: The mechanism by which genetic variants of the thin filament cause hypertrophic cardiomyopathy (HCM) has not been fully elucidated. Induced pluripotent stem cell (iPSC)-derived cardiomyocytes can provide a rapidly generatable disease modeling tool to study… read more here.
Keywords: biomechanics; calcium handling; hypertrophic cardiomyopathy; thin filament ... See more keywords
MED12 regulates a transcriptional network of calcium-handling genes in the heart.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.91920
Abstract: The Mediator complex regulates gene transcription by linking basal transcriptional machinery with DNA-bound transcription factors. The activity of the Mediator complex is mainly controlled by a kinase submodule that is composed of 4 proteins, including… read more here.
Keywords: transcription; heart; handling genes; calcium handling ... See more keywords
Characterization of the mechanism by which a nonsense variant in RYR2 leads to disordered calcium handling
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15265
Abstract: Heterozygous missense variants of the cardiac ryanodine receptor gene (RYR2) cause catecholaminergic polymorphic ventricular tachycardia (CPVT). These missense variants of RYR2 result in a gain of function of the ryanodine receptors, characterized by increased sensitivity… read more here.
Keywords: variant ryr2; calcium handling; calcium; nonsense variant ... See more keywords
Impaired calcium handling mechanisms in atrial trabeculae of diabetic patients
Sign Up to like & getrecommendations! Published in 2023 at "Physiological Reports"
DOI: 10.14814/phy2.15599
Abstract: The aim of this study was to investigate cardiomyocyte Ca2+ handling and contractile function in freshly excised human atrial tissue from diabetic and non‐diabetic patients undergoing routine surgery. Multicellular trabeculae (283 ± 20 μm in diameter) were dissected… read more here.
Keywords: calcium handling; non diabetic; impaired calcium; diabetic patients ... See more keywords
Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201690
Abstract: We show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling. The adult heart develops hypertrophy to reduce ventricular wall stress… read more here.
Keywords: calcium handling; hypertrophy; plin5; cardiomyocyte ... See more keywords
Calcium Handling Defects and Cardiac Arrhythmia Syndromes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00072
Abstract: Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization… read more here.
Keywords: handling defects; arrhythmia syndromes; calcium handling; physiology ... See more keywords
Circulating microRNA-423 attenuates the phosphorylation of calcium handling proteins in atrial fibrillation
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12702
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that control patterns of gene expression by inducing the degradation of mRNAs. In addition, miRNAs are known to serve an important role in the pathogenesis of atrial fibrillation (AF).… read more here.
Keywords: handling proteins; mir 423; calcium; calcium handling ... See more keywords