Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201700196
Abstract: Recently, an innovative paradigm has been proposed in macromolecular therapeutics for treatment of B-cell lymphomas that can specifically kill cancer cells without a drug. The design rationale of this drug-free macromolecular therapeutic (DFMT) system is… read more here.
Keywords: free macromolecular; drug; drug free; macromolecular therapeutics ... See more keywords
Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109020
Abstract: Alzheimer's disease (AD), characterized by impairment of cognitive functions, mainly affects the elderly worldwide. We have previously designed and synthesized a series of memantine nitrate derivatives with vessel dilatory effects. Some of novel compounds have… read more here.
Keywords: glutamate induced; induced excitotoxicity; memantine nitrate; calcium ... See more keywords
Astrocytic mitochondria in adult mouse brain slices show spontaneous calcium influx events with unique properties.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102383
Abstract: Astrocytes govern critical aspects of brain function via spontaneous calcium signals in their soma and processes. A significant proportion of these spontaneous astrocytic calcium events are associated with mitochondria, however, the extent, sources, or kinetics… read more here.
Keywords: adult mouse; spontaneous calcium; astrocytic mitochondria; calcium ... See more keywords
Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.10.012
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Native Americans used plants from the genus Echinacea to treat a variety of different inflammatory conditions including swollen gums, sore throats, skin inflammation, and gastrointestinal disorders. Today, various Echinacea spp. preparations are used… read more here.
Keywords: calcium; calcium influx; cell; mast cell ... See more keywords
Increased Calcium Influx through L-type Calcium Channels in Human and Mouse Neural Progenitors Lacking Fragile X Mental Retardation Protein
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.11.003
Abstract: Summary The absence of FMR1 protein (FMRP) causes fragile X syndrome (FXS) and disturbed FMRP function is implicated in several forms of human psychopathology. We show that intracellular calcium responses to depolarization are augmented in… read more here.
Keywords: neural progenitors; type; calcium; calcium influx ... See more keywords
The restriction of calcium influx in metaphase and post‐metaphase stages of cell division revealed by imaging secondary ion mass spectrometry (SIMS)
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Microscopy"
DOI: 10.1111/jmi.13182
Abstract: A secondary ion mass spectrometry (SIMS)‐based isotopic imaging technique of ion microscopy was used for observing calcium influx in single renal epithelial LLC‐PK1 cells. The CAMECA IMS‐3f SIMS instrument, used in the study, is capable… read more here.
Keywords: metaphase; calcium; restriction; calcium influx ... See more keywords
AB0167 Calcium influx kinetics and the characteristics of potassium channels in peripheral t lymphocytes in systemic sclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.5310
Abstract: Background Systemic sclerosis (SSc) is a chronic connective tissue disorder characterized by microvascular injury, fibrosis and autoimmunity that affects the skin and internal organs. The short-term activation of peripheral blood T lymphocytes plays a crucial… read more here.
Keywords: potassium channels; calcium influx; potassium; activation ... See more keywords
INHIBITION OF GASOTRANSMITTERS PRODUCTION AND CALCIUM INFLUX AFFECT CARDIODYNAMIC VARIABLES AND CARDIAC OXIDATIVE STRESS IN PROPOFOL-ANAESTHETIZED WISTAR MALE RATS.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2018-0719
Abstract: It has been assumed that the cardioprotective effects of propofol are due to its non-anaesthetic pleiotropic cardiac and vasodilator effects, in which gasotransmitters (NO, H2S and CO) as well as calcium influx could be involved.… read more here.
Keywords: propofol; cardiac oxidative; inhibition; calcium influx ... See more keywords
Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0251726
Abstract: Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline. Neutrophil extracellular trap (NET) formation is the most dramatic manifestation of PAD4-mediated hypercitrullination reaction in neutrophils,… read more here.
Keywords: citrullinated histone; histone; net formation; calcium influx ... See more keywords
6-O-angeloylplenolin inhibits anti-IgE-stimulated human mast cell activation via suppressing calcium influx and ERK phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64132.14120
Abstract: Objective(s): Mast cells are important immune cells that primarily localize in the interface between the host and external environment, and protect us from pathogen infection. However, they are also involved in the pathology of allergic… read more here.
Keywords: calcium; erk phosphorylation; mast; influx erk ... See more keywords
N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer’s disease and schizophrenia models
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.335793
Abstract: G l u ta m ate i s t h e m a i n exc i ta to r y neurotransmitter in the brain and binds to two major classes of receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazole… read more here.
Keywords: alzheimer disease; nmda receptors; calcium influx; receptor ... See more keywords