Ryanodine receptor 2–mediated calcium leak is associated with increased glyoxalase I in the aging brain
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DOI: 10.1172/jci.insight.184041
Abstract: Alzheimer disease (AD) is characterized by plaques and tangles, including calcium dysregulation and glycated products produced by reactive carbonyl compounds. AD brains have increased glyoxalase I (GLO1), a major scavenger of inflammatory carbonyl compounds, at… read more here.
Keywords: ryr2; calcium leak; increased glyoxalase; ryanodine receptor ... See more keywords
Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes
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DOI: 10.7554/elife.53999
Abstract: Most glucose is processed in muscle, for energy or glycogen stores. Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca2+]cytosol. 42% of MHS patients have hyperglycemia. We show that phosphorylated glycogen phosphorylase (GPa), glycogen… read more here.
Keywords: calcium leak; intracellular calcium; muscle; ca2 cytosol ... See more keywords