Near Infrared-Activatable Nanomodulator Enabling Self-Amplifying Calcium Overload and Oxidative Stress for Precision Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202503914
Abstract: Calcium interference therapy (CIT) is a promising cancer therapeutic strategy, but its efficacy is limited by intrinsic cellular calcium regulation. To address this limitation, herein, a near-infrared (NIR)-responsive nanoplatform, UC@COFs@CaO2-HA/PAG/ICG (UCCPI), integrating dual-amplified CIT with… read more here.
Keywords: cancer; calcium overload; therapy; overload oxidative ... See more keywords
Cu–Ferrocene‐Functionalized CaO2 Nanoparticles to Enable Tumor‐Specific Synergistic Therapy with GSH Depletion and Calcium Overload
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100241
Abstract: Abstract The conversion of endogenous H2O2 into toxic hydroxyl radical (•OH) via catalytic nanoparticles is explored for tumor therapy and received considerable success. The intrinsic characteristics of microenvironment in tumor cells, such as limited H2O2… read more here.
Keywords: ferrocene; cao2 nanoparticles; calcium overload; therapy ... See more keywords
Capsaicin-Decorated Semiconducting Polymer Nanoparticles for Light-Controlled Calcium-Overload/Photodynamic Combination Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200152
Abstract: Calcium-overload cancer therapy has gained more and more attention owing to its good therapeutic efficacy with low side effect. However, conventional calcium-overload therapy is achieved by introducing an additional calcium element into the tumor site… read more here.
Keywords: calcium; calcium overload; semiconducting polymer; therapy ... See more keywords
NIR-II Absorbed Dithienopyrrole-Benzobisthiadiazole Based Nanosystems for Autophagy Inhibition and Calcium Overload Enhanced Photothermal Therapy.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202309891
Abstract: Although the current cancer photothermal therapy (PTT) can produce a powerful therapeutic effect, tumor cells have been proved a protective mechanism through autophagy. In this study, a novel hybrid theranostic nanoparticle (CaCO3@CQ@pDB NPs, CCD NPs)… read more here.
Keywords: tumor; calcium overload; photothermal therapy; therapy ... See more keywords
Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-018-5297-8
Abstract: Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early… read more here.
Keywords: acute pancreatitis; overload acinar; calcium overload; acinar cells ... See more keywords
LPS-induced vein endothelial cell injury and acute lung injury have Btk and Orai 1 to regulate SOC-mediated calcium influx.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107039
Abstract: Patients with sepsis and sepsis-related complications have a high mortality. Endothelial cell dysfunction plays a central role in sepsis pathophysiological process. In sepsis patients, endothelial cell apoptosis is associated with intracellular calcium overload. Multiple functions… read more here.
Keywords: lps induced; endothelial cell; calcium overload; calcium ... See more keywords
Impact of calcium overload on bone and mineral metabolism at 55 hemodialysis centers in Lima
Sign Up to like & getrecommendations! Published in 2018 at "Nefrologia"
DOI: 10.1016/j.nefroe.2018.03.008
Abstract: Abstract Background Mineral and bone metabolism disorders are common complications in hemodialysis patients that present significant geographical variability. Objectives The objective of this study was to assess these disorders for the first time in hemodialysis… read more here.
Keywords: hemodialysis; metabolism; bone; calcium overload ... See more keywords
Acidity-Responsive Fe-PDA@CaCO3 Nanoparticles for Photothermal-Enhanced Calcium-Overload- and Reactive-Oxygen-Species-Mediated Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c09143
Abstract: Calcium-overload-mediated tumor therapy has received considerable interest in oncology. However, its efficacy has been proven to be inadequate due to insufficient calcium ion concentration at the tumor site coupled with challenges in facilitating efficient calcium… read more here.
Keywords: calcium; tumor; calcium overload; tumor therapy ... See more keywords
Enhancing Photodynamic Therapy Efficacy via Photo-Triggered Calcium Overload and Oxygen Delivery in Tumor Hypoxia Management.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c21452
Abstract: Background: Photodynamic therapy (PDT) has emerged as a promising treatment for cancer, primarily due to its ability to generate reactive oxygen species (ROS) that directly induce tumor cell death. However, the hypoxic microenvironment commonly found… read more here.
Keywords: calcium overload; tumor hypoxia; oxygen; delivery ... See more keywords
A mitochondria‐targeting and G‐quadruplex structure‐binding ligand inducing calcium overload and ferroptosis in human cancer cells
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DOI: 10.1111/bph.70061
Abstract: Regulation of mitochondrial calcium overload and ferroptosis with mitochondria‐targeting ligands is an attractive anticancer strategy but it remains a challenge. The aim of the present study was to demonstrate that a mitochondria‐targeting and mtDNA G‐quadruplex‐binding… read more here.
Keywords: overload ferroptosis; calcium overload; mitochondria targeting;
Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis
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DOI: 10.1155/2021/6643615
Abstract: Myocardial ischemia/reperfusion injury (MI/RI) is an urgent problem with a great impact on health globally. However, its pathological mechanisms have not been fully elucidated. Hydroxysafflor yellow A (HSYA) has a protective effect against MI/RI. This… read more here.
Keywords: hsya; apoptosis; effect; calcium overload ... See more keywords