Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies
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DOI: 10.1002/advs.201903337
Abstract: Abstract Calcium oxalate (CaOx) crystal‐induced nephropathies comprise a range of kidney disorders, for which there are no efficient pharmacological treatments. Although CaOx crystallization inhibitors have been suggested as a therapeutic modality already decades ago, limited… read more here.
Keywords: caox; treatment; crystallization; calcium oxalate ... See more keywords
Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury
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DOI: 10.1002/advs.202411735
Abstract: During the formation of kidney stones, the interaction between crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, which in turn promote stone formation. However, the molecular mechanisms underlying these changes in… read more here.
Keywords: calcium oxalate; caox crystal; deposition; enhancer ... See more keywords
Renal Calcium Oxalate Deposits Induce a Pro‐Atherosclerotic and Pro‐Osteoporotic Response in Mice
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DOI: 10.1002/jcb.25924
Abstract: Urinary stone disease (USD) is increasing in adult and pediatric populations. Adult and pediatric studies have demonstrated decreased bone mineral density and increased fracture rates. USD has also been independently linked to increased rates of… read more here.
Keywords: array showed; upregulation genes; mice; calcium oxalate ... See more keywords
Morphology and composition of calcium oxalate monohydrate phytoliths in the bark of Betula ermanii (stone birch): Case study from Sakhalin Island
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DOI: 10.1002/jemt.24636
Abstract: The morphology of calcium oxalate monohydrate precipitates (COM, Ca(C2O4)·H2O, P21/c, whewellite) occurring as crystals or intergrowths, as well as distribution of crystal‐bearing idioblasts, have been studied for the first time in the bark of stone… read more here.
Keywords: calcium oxalate; stone birch; betula ermanii; oxalate monohydrate ... See more keywords
Protein Network Analysis and Functional Studies of Calcium Oxalate Crystal‐Induced Cytotoxicity in Renal Tubular Epithelial Cells
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DOI: 10.1002/pmic.201800008
Abstract: Our previous expression study has reported a set of proteins with altered levels in renal tubular cells after exposure to calcium oxalate monohydrate (COM) crystals, which are the main composition of kidney stones. However, their… read more here.
Keywords: protein network; analysis; renal tubular; calcium oxalate ... See more keywords
Analyses of long non-coding RNA and mRNA profiling using RNA sequencing in calcium oxalate monohydrate-stimulated renal tubular epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Urolithiasis"
DOI: 10.1007/s00240-018-1065-7
Abstract: To study the expression profiles of lncRNA and mRNA in the calcium oxalate monohydrate-attached HK-2 cells, and investigate the association between critical lncRNA expression level and renal injury. The HK-2 cells were treated with crystal… read more here.
Keywords: rna; oxalate monohydrate; oxalate crystals; calcium oxalate ... See more keywords
Selective protein enrichment in calcium oxalate stone matrix: a window to pathogenesis?
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DOI: 10.1007/s00240-019-01131-3
Abstract: Urine proteins are thought to control calcium oxalate stone formation, but over 1000 proteins have been reported in stone matrix obscuring their relative importance. Proteins critical to stone formation should be present at increased relative… read more here.
Keywords: stone; matrix; stone matrix; calcium oxalate ... See more keywords
Impact of age and renal function on urine chemistry in patients with calcium oxalate kidney stones
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DOI: 10.1007/s00240-021-01254-6
Abstract: Nephrolithiasis is associated with an increased risk of chronic kidney disease, and its incidence varies with age. However, little is known on the combined impact of aging and declining renal function on urinary risk factors… read more here.
Keywords: age; chemistry; creatinine clearance; calcium oxalate ... See more keywords
Comparative functional analysis of the urinary tract microbiome for individuals with or without calcium oxalate calculi
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DOI: 10.1007/s00240-022-01314-5
Abstract: Individuals with urinary stone disease (USD) exhibit dysbiosis in the urinary tract and the loss of Lactobacillus that promote urinary tract health. However, the microbial metabolic functions that differentiate individuals with USD from healthy individuals… read more here.
Keywords: stone; calcium oxalate; tract; urinary tract ... See more keywords
Establishment and application of a nomogram diagram for predicting calcium oxalate stones in patients with urinary tract stones
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DOI: 10.1007/s00240-024-01542-x
Abstract: This retrospective study aims to examine the correlation between calcium oxalate (CaOx) stones and common clinical tests, as well as urine ionic composition. Additionally, we aim to develop and implement a personalized model to assess… read more here.
Keywords: calcium oxalate; oxalate stones; patients urinary; urinary tract ... See more keywords
Carboxymethylated Rhizoma alismatis polysaccharides reduces the risk of calcium oxalate stone formation by reducing cellular inflammation and oxidative stress
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DOI: 10.1007/s00240-024-01565-4
Abstract: This study aims to elucidate the mechanism and potential of Rhizoma alismatis polysaccharides (RAPs) in preventing oxidative damage to human renal proximal tubule epithelial cells. The experimental approach involved incubating HK-2 cells with 100 nm… read more here.
Keywords: rhizoma alismatis; alismatis polysaccharides; calcium oxalate;