Calcium sensing receptor hyperactivation through viral envelop protein E of SARS CoV2: A novel target for cardio‐renal damage in COVID‐19 infection
Sign Up to like & getrecommendations! Published in 2021 at "Drug Development Research"
DOI: 10.1002/ddr.21810
Abstract: Over the recent decades, a number of new pathogens have emerged within specific and diverse populations across the globe, namely, the Nipah virus, the Ebola virus, the Zika virus, and coronaviruses (CoVs) to name a… read more here.
Keywords: protein; cardio renal; sars cov2; calcium ... See more keywords
Pathological role of the calcium‐sensing receptor in sepsis‐induced hypotensive shock: Therapeutic possibilities and unanswered questions
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21959
Abstract: Sepsis is a life‐threatening disease involving multiorgan dysfunction, prompted by an unregulated host response to infection. Shock is a complication of sepsis in which the circulatory and cellular metabolism anomalies are significant enough to raise… read more here.
Keywords: sepsis; calcium; calcium sensing; inflammatory cytokines ... See more keywords
Cell Surface Calcium‐Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca2+ Sensing but Not G Protein Interaction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4651
Abstract: The calcium‐sensing receptor is a homodimeric class C G protein‐coupled receptor (GPCR) that senses extracellular Ca2+ (Ca2+o) via a dimeric extracellular Venus flytrap (VFT) unit that activates G protein‐dependent signaling via twin Cysteine‐rich domains linked… read more here.
Keywords: gene dosage; receptor; calcium sensing;
Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR).
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_41
Abstract: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that plays a key role in calcium homeostasis, by sensing free calcium levels in blood and regulating parathyroid hormone secretion in response. The CaSR is highly… read more here.
Keywords: receptor casr; casr; calcium; sensing receptor ... See more keywords
Calcium-sensing receptor: evidence and hypothesis for its role in nephrolithiasis
Sign Up to like & getrecommendations! Published in 2018 at "Urolithiasis"
DOI: 10.1007/s00240-018-1096-0
Abstract: Calcium-sensing receptor (CaSR) is a plasma-membrane G protein-coupled receptor activated by extracellular calcium and expressed in kidney tubular cells. It inhibits calcium reabsorption in the ascending limb and distal convoluted tubule when stimulated by the… read more here.
Keywords: nephrolithiasis; role; casr; calcium ... See more keywords
Calcium-sensing receptor-mediated mitogen-activated protein kinase pathway improves the status of transplanted mouse embryonic stem cells in rats with acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2987-z
Abstract: Several studies have identified the critical role of calcium-sensing receptors (CaSRs) in cardiac ischaemia/reperfusion injury and cardiac hypertrophy and have demonstrated that CaSRs induce myocardial apoptosis by activating MAPKs. Using acute myocardial infarction rat models,… read more here.
Keywords: acute myocardial; embryonic stem; myocardial infarction; calcium sensing ... See more keywords
Influence of Ischemic Pre- and Post-Conditioning on Cardiac Expression of Calcium-Sensing Receptor
Sign Up to like & getrecommendations! Published in 2017 at "BioNanoScience"
DOI: 10.1007/s12668-016-0316-8
Abstract: Ischemic heart disease is a common cause of patients’ death worldwide. Recently, cardiac pre- and post-conditioning (IPC, IPoC) were indentified to reduce infarct size. Nevertheless, not only infarct size but also post-infarct remodelling is critical… read more here.
Keywords: post conditioning; ipc ipoc; pre post; infarct size ... See more keywords
Calcium sensing receptor contribute to early brain injury through the CaMKII/NLRP3 pathway after subarachnoid hemorrhage in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.081
Abstract: The subversive role of Calcium sensing receptor (CaSR) in cerebral ischemia and traumatic brain injury has been recently reported. Nevertheless, the role of CaSR in early brain injury (EBI) after subarachnoid hemorrhage (SAH) remains unexplored.… read more here.
Keywords: early brain; camkii; brain injury; brain ... See more keywords
Autosomal dominant hypocalcemia due to a truncation in the C-tail of the calcium-sensing receptor
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2016.08.032
Abstract: Autosomal Dominant Hypocalcemia (ADH) is an endocrine disorder due to activating mutations of the calcium-sensing receptor (CASR) gene. We report on a young boy who presented low serum calcium with hypercalciuria, hyperphosphatemia and low serum… read more here.
Keywords: dominant hypocalcemia; hypocalcemia; autosomal dominant; calcium ... See more keywords
Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.06.004
Abstract: CONTEXT A subset of PHPT patients exhibit a more severe disease phenotype characterized by bone loss, fractures, recurrent nephrolithiasis, and other dysfunctions, but the underlying reasons for this disparity in clinical presentation remain unknown. OBJECTIVE… read more here.
Keywords: ec50; bone mineral; phpt; mineral density ... See more keywords
NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular immunology"
DOI: 10.1016/j.molimm.2017.07.012
Abstract: NPS 2143, a novel and selective antagonist of calcium-sensing receptor (CaSR) has been reported to possess anti-inflammatory activity. In the present study, we examined the protective effect of NPS 2143 on lipopolysaccharide (LPS)-induced acute lung… read more here.
Keywords: nps; nps 2143; antagonist; sensing receptor ... See more keywords