Molecular Effects of Cardiac Troponin DCM Mutations on Calcium Sensitivity and Myofilament Activation - an Integrated Multi-Scale Modeling Study
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1744
Abstract: Mutations in cTnC (D75Y, E59D and G159D), a key regulatory protein of myofilament contraction, have been associated with dilated cardiomyopathy (DCM). Despite reports of altered myofilament function in these mutants, the underlying molecular alterations caused… read more here.
Keywords: ctnc; calcium sensitivity; molecular effects; multi scale ... See more keywords
Cardiac ventricular muscle mechanical properties through the first year of life in Sprague-Dawley rats
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111359
Abstract: Advanced age has been shown to result in decreased compliance, shortening velocity, and calcium sensitivity of the heart muscle. Even though cardiac health has been studied extensively in elderly populations, relatively little is known about… read more here.
Keywords: first year; age; year life; calcium sensitivity ... See more keywords
Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00196
Abstract: Despite large investments from academia and industry, heart failure, which results from a disruption of the contractile apparatus, remains a leading cause of death. Cardiac muscle contraction is a calcium-dependent mechanism, which is regulated by… read more here.
Keywords: calcium; diphenyl moieties; small molecules; calcium sensitivity ... See more keywords
Abstract 191: Difference in Calcium Sensitivity Between Right and Left Ventricles With Lower Expression of Calcium Binding Proteins in Right Ventricular Myocytes
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.191
Abstract: Left ventricle (LV) and right ventricle (RV) have distinctive structural and functional characteristics as well as heterogeneous physiological properties. The RV is exposed to a relatively low pulmonary vasculature, which results in less mechanical afterload.… read more here.
Keywords: difference; calcium binding; binding proteins; calcium sensitivity ... See more keywords
Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00516
Abstract: Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular… read more here.
Keywords: length; calcium sensitivity; cardiomyopathy associated; dilated cardiomyopathy ... See more keywords